Protein Alignment nAChRbeta3 and lgc-17

DIOPT Version :10

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_510028.2
• Gene: lgc-17 / 187976
• WormBaseID: WBGene00011359
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 365
• Identity: 81/365 - (22%)
• Similarity: 156/365 - (42%)
• Gaps: 61/365 - (16%)

  Fly    52 DRLHAGLFTNYDSDVQPVFQGT----PTNVSLEMV-----------VTYIDIDELNGKLTTHCWL 101
            |.|...||.|||..:..|:..:    |::.....|           :..:::.|...|::....|
 Worm    37 DNLTRDLFANYDPTISSVYSSSFDYEPSHNHTRTVDRWNYTILLYYLKLVEVQEPEEKVSVVLEL 101

  Fly   102 NLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQ------VTLSHDGHFR 160
            ..:|.|....|..|.|.||..:.::..:||:|.::.|..:|   :.:.:      |::...|:.:
 Worm   102 VEQWYDPRLSWNSSLYSNIPTVFVRQEKVWSPTLSAFGVNE---IIDFRDQDFRIVSIDDIGYIQ 163

  Fly   161 WMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLD--HDDLVQ------- 216
            .......::.|.:::..:|.|.|:|::..       .||.....:.:.|:  ::.::|
 Worm   164 DYLSVRVSSNCPMDVSRFPFDSQTCQICF-------CLPIFNIRQVKILNEIYEGILQEKIIKTM 221

  Fly   217 -SPEWEIVDSRAHFVSQ----DYYGYME---YTLTAQRRSSMYTAVIYTPASCIVILALSAFWLP 273
             :.||::| |..:.|.|    |.||.|:   :.:|.:|....|..:|..|:..|..:::...:|.
 Worm   222 GNSEWKVV-SLTNRVEQLKYDDDYGNMDLAVFEITIRRNPLYYIYMIVFPSFVINGISIVGIFLK 285

  Fly   274 PHMGGEKIMINGLLIIVIAAFLM-YFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYL- 336
            ......|:.: ||..|:...|:: ..|..:| .:.:.||:.|:...:||.:.::..|.||:..|
 Worm   286 SADKMSKLNV-GLTNIMTMTFILGVMADKIP-RTGSIPLLGIYIIINLLIMIIAITVVVLITELR 348

  Fly   337 --ATGKHKRRLPEALRKLLHGHLG-----TWLLLSVFSTT 369
              |..:.|.:.....|| |...||     |..:|..|.||
 Worm   349 QWAVPRLKLKKSYISRK-LETFLGSPIEYTCAILLEFLTT 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	81/365 (22%)
lgc-17	NP_510028.2	LGIC_ECD_cation	77..259	CDD:349790	37/192 (19%)
		Cys-loop	174..188	CDD:349790	4/13 (31%)
		LGIC_TM	261..>317	CDD:476813	12/57 (21%)
		TM1 helix	265..286	CDD:349850	4/20 (20%)
		TM2 helix	294..315	CDD:349850	5/21 (24%)