DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and lgc-17

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_510028.2	Gene:	lgc-17 / 187976	WormBaseID:	WBGene00011359	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	81/365 - (22%)
Similarity:	156/365 - (42%)	Gaps:	61/365 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DRLHAGLFTNYDSDVQPVFQGT----PTNVSLEMV-----------VTYIDIDELNGKLTTHCWL 101
            |.|...||.|||..:..|:..:    |::.....|           :..:::.|...|::....|
Worm    37 DNLTRDLFANYDPTISSVYSSSFDYEPSHNHTRTVDRWNYTILLYYLKLVEVQEPEEKVSVVLEL 101

  Fly   102 NLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQ------VTLSHDGHFR 160
            ..:|.|....|..|.|.||..:.::..:||:|.::.|..:|   :.:.:      |::...|:.:
Worm   102 VEQWYDPRLSWNSSLYSNIPTVFVRQEKVWSPTLSAFGVNE---IIDFRDQDFRIVSIDDIGYIQ 163

  Fly   161 WMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLD--HDDLVQ------- 216
            .......::.|.:::..:|.|.|:|::..       .||.....:.:.|:  ::.::|
Worm   164 DYLSVRVSSNCPMDVSRFPFDSQTCQICF-------CLPIFNIRQVKILNEIYEGILQEKIIKTM 221

  Fly   217 -SPEWEIVDSRAHFVSQ----DYYGYME---YTLTAQRRSSMYTAVIYTPASCIVILALSAFWLP 273
             :.||::| |..:.|.|    |.||.|:   :.:|.:|....|..:|..|:..|..:::...:|.
Worm   222 GNSEWKVV-SLTNRVEQLKYDDDYGNMDLAVFEITIRRNPLYYIYMIVFPSFVINGISIVGIFLK 285

  Fly   274 PHMGGEKIMINGLLIIVIAAFLM-YFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYL- 336
            ......|:.: ||..|:...|:: ..|..:| .:.:.||:.|:...:||.:.::..|.||:..|
Worm   286 SADKMSKLNV-GLTNIMTMTFILGVMADKIP-RTGSIPLLGIYIIINLLIMIIAITVVVLITELR 348

  Fly   337 --ATGKHKRRLPEALRKLLHGHLG-----TWLLLSVFSTT 369
              |..:.|.:.....|| |...||     |..:|..|.||
Worm   349 QWAVPRLKLKKSYISRK-LETFLGSPIEYTCAILLEFLTT 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	81/365 (22%)
		Neur_chan_LBD	52..247	CDD:280998	47/232 (20%)
		Neur_chan_memb	255..434	CDD:280999	32/124 (26%)
lgc-17	NP_510028.2	LGIC_ECD_cation	77..259	CDD:349790	37/192 (19%)
		LGIC_TM	261..>317	CDD:365787	12/57 (21%)
		TM1 helix	261..286	CDD:349850	5/24 (21%)
		TM2 helix	294..315	CDD:349850	5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820