DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and lgc-15

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_510025.2	Gene:	lgc-15 / 187973	WormBaseID:	WBGene00011356	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	356	Identity:	76/356 - (21%)
Similarity:	149/356 - (41%)	Gaps:	72/356 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LHAGLFTNYDSDVQPVF-QGTPT-------------NVSLEMV-VTYIDIDELNGKLTTHCWLNL 103
            |...||:.||:.:.||: :..||             |.:|.:. :..:::.|...|::....:..
Worm    38 LTKNLFSGYDATISPVYTKVDPTQPLGHDPDAPGRWNYTLLLFSLKLVEVTEPQEKVSVVMEVME 102

  Fly   104 RWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQ---VTLSHDGHFRWMPPA 165
            .|.|....|....||:|..|..:.:.||:|.::.|...|...:.:|.   |.::..|........
Worm   103 YWFDARLTWNKEDYDDIASIYTRQANVWSPTLSAFGVSELVDLRDTDFRLVGITSYGMVNTYVSV 167

  Fly   166 VYTAYCELNMLNWPHDKQSCKLK-----IGSWGLKV-------VLPENG--------------TA 204
            :.:|.|.:::..:|.|.|:|:::     ..|:.:::       ||..|.              |.
Worm   168 LVSANCPMDVYKFPFDYQTCQIRFCIPVFTSYEVEIFNEIYAGVLTSNAWKTMGNSEWNLVNLTH 232

  Fly   205 RGESLDHDDLVQSPEWEIVDSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSA 269
            |.|:|.:||              .|.:.| .|..|  :..:|....|..:|..|:..|.::::..
Worm   233 RVETLKYDD--------------GFANLD-LGTFE--IKIRRNPLYYIYMIIFPSFIINVVSIIG 280

  Fly   270 FWLPPHMGGEKI-MIN-GLLIIVIAAFLM-YFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEV 331
            .:|   .|.:|: .:| ||..|:...|:: ..|..:| .:...||:.::..|:|:.:.::..:..
Worm   281 VFL---KGADKMSKLNVGLTNIMTMTFILGVMADKIP-RTGTIPLLGVYIITNLVIMLIAIGIVT 341

  Fly   332 LVLYL---ATGKHKRRLPEALRKLLHGHLGT 359
            ::..|   |:...||:..:..|| |...:||
Worm   342 VINELRRCASPVLKRKQTKLSRK-LESFIGT 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	76/356 (21%)
		Neur_chan_LBD	52..247	CDD:280998	48/236 (20%)
		Neur_chan_memb	255..434	CDD:280999	26/111 (23%)
lgc-15	NP_510025.2	LGIC_ECD_cation	74..258	CDD:349790	39/200 (20%)
		LGIC_TM_cation	260..>343	CDD:349853	18/86 (21%)
		TM1 helix	264..285	CDD:349853	4/23 (17%)
		TM2 helix	293..314	CDD:349853	6/20 (30%)
		TM3 helix	324..343	CDD:349853	2/18 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810