Protein Alignment nAChRbeta3 and lgc-12

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_498656.3
• Gene: lgc-12 / 187855
• WormBaseID: WBGene00020048
• Length: 428
• Species: Caenorhabditis elegans
• Alignment Length: 432
• Identity: 94/432 - (21%)
• Similarity: 163/432 - (37%)
• Gaps: 103/432 - (23%)

  Fly    58 LFTNYDSDVQPV--FQGTPTNVSLEMVVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNI 120
            |..:|....:||  :....|...:..:...::::|.|.::....|....|:|:..||.|.::|.|
 Worm    36 LMKDYYQFTRPVKNYSSMLTVTIMPQIYNLVEVNEQNEQIKLLIWFPQSWKDDYLVWDPDEWDGI 100

  Fly   121 TQITLKSSEVWTPQITLFNG-DEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQS 184
            .:||:..|.||.|...:||. :|...:....|.:.::|........:....|.:::|::|.|.|.
 Worm   101 EKITIPKSMVWLPDGYIFNTVEETDTLDNHNVRVHYNGKVEVDFNKLIDLICPMSVLSFPFDVQL 165

  Fly   185 CKLKIGSWGLKVVLPENGTARGESLDHDDLVQS-------PEWEIVDSRA--------HFVSQD- 233
            |.|:.|||          |.:..:|..:.|..|       .||:||...|        :.:..|
 Worm   166 CALQFGSW----------TYQSHALSFNVLEASVNENNKNSEWDIVAFNATKKVSKYMNLIGGDN 220

  Fly   234 YYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGG---EKIMINGLLIIVIAAFL 295
            .|..:.|.|..:|:...|..||..|...||.::....:.|..:.|   |.:.:....::.:|..|
 Worm   221 VYEEIFYFLEVRRKPLYYIVVILIPTFLIVTVSNIGLFTPHGVHGDREEHVSLGLTTMLTMAVIL 285

  Fly   296 MYFAQLLPVLSNNTPL----VVIFYSTSLLYLSVSTIV---EVLVLYLAT----------GKHKR 343
            ......:|..|...||    |:|.::.|::.:.||.::   ...:||:..          .|||.
 Worm   286 DMVTGQMPKSSEGIPLLGMYVLIEFALSIMAVLVSVLIIFAHERMLYMDAMPPFWIFRLFSKHKN 350

  Fly   344 RLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGI---------- 398
            ::|.|                              ||      |.|:..|||:.:
 Worm   351 QIPLA------------------------------EM------EYDDLRSSPVDLAQELRFCIEK 379

  Fly   399 --NHTEVPGAK-ANQFDWALLATAVDRIS-----FVSFSLAF 432
              .|.|...:| .|:..|....:..|.|.     ||:..:.|
 Worm   380 VRKHLEDLDSKDKNELIWQRFFSCADIICGSCFFFVNCIITF 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	94/432 (22%)
		Neur_chan_LBD	52..247	CDD:280998	49/207 (24%)
		Neur_chan_memb	255..434	CDD:280999	42/216 (19%)
lgc-12	NP_498656.3	Neur_chan_LBD	29..235	CDD:280998	50/208 (24%)
		Neur_chan_memb	242..>345	CDD:280999	20/102 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810