Protein Alignment nAChRbeta3 and acr-20

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001367183.1
• Gene: acr-20 / 187632
• WormBaseID: WBGene00000059
• Length: 556
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 108/539 - (20%)
• Similarity: 194/539 - (35%)
• Gaps: 159/539 - (29%)

  Fly    38 TATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM-VVTYIDIDELNGKLTTHCWL 101
            |.::|......|.||:.:|||       :..:.:.:|..|...| :...|.::|....|..:.|:
 Worm    19 TVSSDQYEIANKILDKYNAGL-------IPSMGKKSPIEVHFSMELYQIISVNEPQQFLMLNAWV 76

  Fly   102 NLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNG-----DEGGLMAETQVTLSHDGH--- 158
            ..||.|....|.|.::.|:|:|.|....:|.|..||:|.     ||...:...:||...:|:
 Worm    77 VERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDENRRLLHAKVTTLGEGNGAF 141

  Fly   159 FRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLDH-----------D 212
            ...:.|.:|...|.||:..:|.|.|||:|..|||          |.....:|:           .
 Worm   142 IELLYPTIYKLSCLLNLRFFPFDVQSCRLLFGSW----------TFDNTKIDYFAFNESQAIGTT 196

  Fly   213 DLVQSPEWEIVDSRAHFVSQDY------YGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFW 271
            :.:::..|.::.:........|      |..:|:.||.||:...|...:..|.|.|..:::..|:
 Worm   197 NCIENEGWNVLSTSVIRHENKYDCCPNNYTLLEFRLTIQRKPLYYIINLIIPTSIITFISIIGFF 261

  Fly   272 LPPHMG---GEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLV 333
            ....:.   .|||.:....::.::..:...:..:|..|:..||:.:||::.:|.:|.|||...:|
 Worm   262 STSSINEPREEKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGLFYTSMILLISFSTICSSVV 326

  Fly   334 LYL-------------------ATGKHKR-RLP-------------EALRKLLHGHLGTWLLLSV 365
            :|:                   |..:..| .:|             |.||:...|...: |...|
 Worm   327 IYVQKQGNLGNPPSKNFMNIARAVNRFIRMEMPLIMKQAYAQKAREEKLRRQQMGRKQS-LWTRV 390

  Fly   366 FSTTGESQAEKTKEMDEHPYE------------------------------------------EA 388
            :....|....|..:..::..:                                          |.
 Worm   391 YKLAREQALRKDVQTSQNSSKFNEVLTPEKLIDNGGKRCTINKDVTCISDSGIVAMGVPTLASED 455

  Fly   389 DEQESSPLGINHTEVPGA-------KAN----------------------------QFDWALLAT 418
            |:|:.|.|.:..|..|..       ||:                            ::||  ||.
 Worm   456 DDQDVSLLELETTPTPAMQRPTRLHKASTCGSFDSMMFRQIEVPVSPRTARNLAEIEYDW--LAA 518

  Fly   419 AVDRISFVSFSLAFLILAI 437
            .::||..::|...|::.:|
 Worm   519 LLERIFLITFLFIFVLTSI 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	106/536 (20%)
		Neur_chan_LBD	52..247	CDD:280998	53/220 (24%)
		Neur_chan_memb	255..434	CDD:280999	48/291 (16%)
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	56/230 (24%)
		LGIC_TM_cation	239..>329	CDD:349853	20/89 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100