DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta3 and lgc-5

DIOPT Version :9

Sequence 1:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_501411.4 Gene:lgc-5 / 184620 WormBaseID:WBGene00017543 Length:433 Species:Caenorhabditis elegans


Alignment Length:472 Identity:104/472 - (22%)
Similarity:178/472 - (37%) Gaps:99/472 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 LLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFT-NYDSDVQPVFQGTPTNVSL-EM 81
            ||..|:..|::   ...|:..|....|..|     |...||. .||.:|:|  ..|.|.|:: ..
 Worm     4 LLNSLLTFLVL---RTFGSNTTNVESNTEV-----LLQELFNRTYDVNVKP--SDTLTTVTITPN 58

  Fly    82 VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYD-NITQITLKSSEVWTPQITLFNG----- 140
            ....:.:|:....:.......|:|.|....|..:.:| |...|.:..|.||.|.: :|..     
 Worm    59 TFLLLSMDQTQETILFSQEFLLKWYDPILHWNRTLFDYNREWIKISVSRVWVPDV-IFTKRLSVE 122

  Fly   141 ---DEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---------- 192
               ||...||:    |.::|..|...|||.:..|.||:.::|||.|.|.:.:|||          
 Worm   123 SLLDEDMQMAD----LRYNGEIRTSLPAVVSTSCPLNIQDFPHDVQECNISMGSWAFDRTVIVVQ 183

  Fly   193 -GLKVVLPENGTARGESLDHDDLVQSPEWEIVDSRAHFV-SQDY-----YGYMEYTLTAQRRSSM 250
             .:..:||..|...|.|          |||::..||... |.:|     :..:.||:|.||:...
 Worm   184 SSVDEILPLRGRFEGNS----------EWELLSIRAFRTDSFEYSLGTSFSEITYTVTLQRKPVY 238

  Fly   251 YTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAA---FLMYFAQLLPVLSNNTPLV 312
            |..||..|...:..:.:...:.|.....|::....|.:.:.||   .|...:.::|..| ..||:
 Worm   239 YVLVIQAPTFILCTITIFGLFSPNSNENERLSRVELCLNMFAAISMMLQLVSDMMPKAS-RLPLL 302

  Fly   313 VIFYSTSLLYLSVSTIVEVLVLYLATGKHKRRLPEALRKLLHGHLGT-------WL-LLSVFSTT 369
            ..:....:..::.:||..:::.:                 :|.|:.|       || .|.:....
 Worm   303 GNYIIAEIFVVTAATIAAIVIQH-----------------VHHHVHTNATCPPKWLRCLVLCDCM 350

  Fly   370 GESQAEKTKEMDEHPYEEADEQESSPLGINHT--------------EVPGAKANQFDWALLATAV 420
            .|....||..:..   .:..|...:|:.:..:              |:.....||..|..:....
 Worm   351 REEFPSKTSSVSS---MDVPENIIAPVSLLKSSLHKTAFLVRDTLQEMSRINENQLLWLKILDKT 412

  Fly   421 DRISFVSFSLAFLILAI 437
            |.:..:.|.:|.:::.|
 Worm   413 DLMCLILFQVANVVITI 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta3NP_525098.1 LIC 39..437 CDD:273305 98/450 (22%)
Neur_chan_LBD 52..247 CDD:280998 60/222 (27%)
Neur_chan_memb 255..434 CDD:280999 32/203 (16%)
lgc-5NP_501411.4 LGIC_ECD_cation 51..235 CDD:349790 52/198 (26%)
LGIC_TM 238..>323 CDD:365787 16/85 (19%)
TM1 helix 238..261 CDD:349850 4/22 (18%)
TM2 helix 273..294 CDD:349850 4/20 (20%)
TM3 helix 304..323 CDD:349850 2/18 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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