Protein Alignment nAChRbeta3 and lgc-22

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001255259.1
• Gene: lgc-22 / 184533
• WormBaseID: WBGene00017483
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 395
• Identity: 74/395 - (18%)
• Similarity: 140/395 - (35%)
• Gaps: 85/395 - (21%)

  Fly    16 LPLLLQMLMGMLLMGLTSVPGATATADPK-----------------NANV-KALDRLHAG----- 57
            |.||:...:...|.......|....||||                 .||. |:......|
 Worm     2 LRLLIATSLAATLAWAAGTAGGCEDADPKCTEWAATGECATNAVWMMANCRKSCHSCQGGDRAWK 66

  Fly    58 LFTNYDSDVQPVFQGTPTN----VSLEMV-VTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQY 117
            |.|:    :|..:|....|    |.:|.| :..::|||....:.......|.|.|....|...|:
 Worm    67 LRTH----IQTTYQNATDNKTKVVRVESVRINNVEIDERRQNVKVFGRFVLSWNDTMVSWDKEQW 127

  Fly   118 DNITQITLKSSEVWTPQITLFNGDEGGLMAETQVT-----LSHDGHFRWMPPAVYTAYCELNMLN 177
             .::.:.....::|||.|...||  |......|||     .::.|.........:|........:
 Worm   128 -GLSWLNFYWIQIWTPNIVQING--GSTSNPGQVTSKVLAANYTGQIYLWSDFSFTTPFRFQYED 189

  Fly   178 WPHDKQSCKLK-----------------------------IGSWGLKVV-------LPENGTARG 206
            :|:|.|....|                             :..|.::.|       .|:||....
 Worm   190 YPNDMQRVCYKFDDKRLMAVHFTVAEGVKNKEREATTDPFVSGWKIEDVEVVSITHSPDNGGTGK 254

  Fly   207 ESLDHDDLVQSPEWEIVDSRAH-FVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAF 270
            ..|:....|:    ::.|.|.: |..|...|  |..::.:|.:..:||.:..||....:..|:|.
 Worm   255 NGLESPYTVE----QLSDPRRNPFDVQADNG--ELCISLRRNAVYFTAEMLLPALITSLFTLAAV 313

  Fly   271 WLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLY 335
            :.  .:...:.::.|..::.....|:..:|.||..:.:||.::.:...::.:.::..::.:::..
 Worm   314 FF--QLSKTQPILLGFSVVAQILSLILVSQRLPSFTAHTPTILKYAGFNMTWTAILFVISLVLER 376

  Fly   336 LATGK 340
            :||.:
 Worm   377 MATSQ 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	69/372 (19%)
		Neur_chan_LBD	52..247	CDD:280998	46/246 (19%)
		Neur_chan_memb	255..434	CDD:280999	13/86 (15%)
lgc-22	NP_001255259.1	ShKT	24..58	CDD:214586	7/33 (21%)
		LGIC_ECD	85..249	CDD:355788	30/166 (18%)
		Cys-loop	183..198	CDD:349787	3/14 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910