Protein Alignment nAChRbeta3 and lgc-23

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_510016.2
• Gene: lgc-23 / 182622
• WormBaseID: WBGene00007594
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 403
• Identity: 88/403 - (21%)
• Similarity: 157/403 - (38%)
• Gaps: 104/403 - (25%)

  Fly    26 MLLMGLTSVPGATATADPKNANVKA-LDRLHAGLFTNYDSDVQPVFQGT-----PTNVSLEMVVT 84
            |:|:...::|...:.||.::...:| ||  |..|    ..||.....|:     |..:..::.:.
 Worm     6 MILVLFNTIPIRVSEADEESERHQAYLD--HRKL----KEDVLGPLDGSMPSELPVFIGAQLKLD 64

  Fly    85 YID-IDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLK-----SSEVWTPQITLFNGDEG 143
            :|. :||..|.||....:...|.||...|.||.|...|:..|:     ..::|.|:|.:.|..|.
 Worm    65 HISRVDEKTGFLTLALTVKFMWSDERLQWDPSHYSGFTRTRLEFVDFWLYQIWKPRIYMTNTYER 129

  Fly   144 ------GLMAETQVTLS-HD-GHFRWMPPAVYTAYCELNMLNWPHDKQSCKLK-----------I 189
                  .|::.|.|.:. |. |........:...:|.|:...:|||.|:|...           :
 Worm   130 RQSKTIDLLSNTLVEMDIHSKGFVMTTTKILLKTFCFLDFKGYPHDFQNCSFSFIPNMNANDIFL 194

  Fly   190 GSWGLKVVLPENGTARGESLDHDDLVQSPEWEIVDSRAHFVSQDYY------------------- 235
            ||..||....::.|      |...:|:..:::|.|    .|::|.|
 Worm   195 GSSMLKAKFTKDFT------DPQQVVRVQDFQIND----VVTEDLYLFMNRIVLHDLTREPRSLV 249

  Fly   236 -GYMEYTLTAQRRSSMYTAVIYTP----ASCIVILAL--SAFWLPPHMGGEKIMINGLLIIVIAA 293
             .::.:|:..||::......:|.|    .:|::|...  |.:.||            ||:..:.:
 Worm   250 RSFVSFTIVLQRKNVYVHLQLYAPMIFICTCLIISGFLPSEYALP------------LLVFNLIS 302

  Fly   294 FLMYF---AQLLPVLSNNTPLVVIFYSTSLLYLSVSTI-VEVLVLYLATGKHK------RRLP-- 346
            ..:||   ..:||...:.||.:.:. :|..|..::|.| .::.::.:.|.|.|      .:.|
 Worm   303 EYLYFHNIKDVLPTDFDGTPTIALI-ATFTLAETMSIIGWKMFIITIMTKKQKAYFLNSSKFPLD 366

  Fly   347 ------EALRKLL 353
                  ..||:||
 Worm   367 SGFFNIRVLRRLL 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	85/390 (22%)
		Neur_chan_LBD	52..247	CDD:280998	53/244 (22%)
		Neur_chan_memb	255..434	CDD:280999	27/123 (22%)
lgc-23	NP_510016.2	Neur_chan_LBD	34..262	CDD:367255	52/241 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810