Protein Alignment nAChRbeta3 and acr-12

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_510262.1
• Gene: acr-12 / 181475
• WormBaseID: WBGene00000051
• Length: 573
• Species: Caenorhabditis elegans
• Alignment Length: 558
• Identity: 120/558 - (21%)
• Similarity: 218/558 - (39%)
• Gaps: 166/558 - (29%)

  Fly    20 LQML-MGMLLMGLTSVPGATATADPKNANVKALD-RLHAGLFTNYDSDVQPVFQGTPTNVSLEM- 81
            |||. ....|:.|.:|.|..|....:.|  |.|: :|:..|..:|:...:|| :.:...:::::
 Worm     7 LQMFSFNWALILLVAVGGTNAFKIKRTA--KDLESQLYEDLLFDYNKVPRPV-KNSSDILTVDVG 68

  Fly    82 --VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG- 143
              ::..||:||.|..|||:.||.::|.|.:..|.|.:|..:..:.:.|..:|||.:.|:|...|
 Worm    69 ASLIRIIDVDEKNQVLTTNLWLEMKWNDAKLTWTPEKYGGLKTLHIPSDFIWTPDLVLYNNAAGD 133

  Fly   144 -GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGE 207
             .:...|...::.:|:..|.|||:|.::|.:::..:|:|.|.|::|.|:|          |..|.
 Worm   134 PDITILTDALVTFEGNVYWQPPAIYKSFCPIDVTWFPYDSQKCEMKFGTW----------TYTGR 188

  Fly   208 SLDHDDLVQSPEWEIV-----DSRAHFVSQD-----YYGYMEY---TLTAQRRSSMY-------- 251
               :.||.|.|:.|:|     |:...|:.|.     :|...|:   :||::|.|.:|
 Worm   189 ---YVDLKQLPQEEVVTITKDDNDVEFMQQGMDLSFFYRSAEWDLLSLTSERHSVLYASCCGPEK 250

  Fly   252 -----------------TAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFA 299
                             |..:..|...|.||....|:|..|    ||..:..:::.:..|.:...
 Worm   251 YVDITYYFGLRRKTLFFTCNLILPCFLISILTTFVFYLSDH----KITFSISILVTLTVFFLVLI 311

  Fly   300 QLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL---YLATGKHKRRLPEALRKLLHGHLGTWL 361
            .|:|..|...|:...:..|:::.:::||:|.|:.:   :.:...||  :...:|.:....|...|
 Worm   312 DLMPPTSLVIPMFGRYLITTMILVALSTVVSVITVNFRFRSGSAHK--MSPWIRAVFLKFLPKIL 374

  Fly   362 LLS---------------VFSTTGESQAEKTKEMDEH---------------------------- 383
            |:|               ..|..|.:.|...|..:|:
 Worm   375 LMSRPEKGEVTKQPPLVNAASLVGSNYATAAKAANEYRNKAKGKNNDLMSLRGKPSSQAVLNNTF 439

  Fly   384 ----------------PY-------------EEADEQESSPLG-----------------INHTE 402
                            ||             .:...|:|..:.                 ..|.|
 Worm   440 DMRMRNNDSTVENRLKPYLCAQNNNAPTVAFRKTKRQKSKSVDDVVFMNLLNQVRFIAEHFRHNE 504

  Fly   403 VPGAKANQFDWALLATAVDRISFVSFSL-----AFLIL 435
            :.|..::  ||..:|..:||:..:.||:     .|:||
 Worm   505 LEGEISD--DWTFVAMVLDRLFLIIFSVLNVGTVFIIL 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	113/538 (21%)
		Neur_chan_LBD	52..247	CDD:280998	57/213 (27%)
		Neur_chan_memb	255..434	CDD:280999	46/275 (17%)
acr-12	NP_510262.1	LIC	14..539	CDD:273305	115/548 (21%)
		Neur_chan_LBD	38..264	CDD:280998	60/239 (25%)
		Neur_chan_memb	271..538	CDD:280999	45/274 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910