Protein Alignment nAChRbeta3 and acr-3

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_509129.1
• Gene: acr-3 / 180937
• WormBaseID: WBGene00000043
• Length: 487
• Species: Caenorhabditis elegans
• Alignment Length: 452
• Identity: 98/452 - (21%)
• Similarity: 190/452 - (42%)
• Gaps: 92/452 - (20%)

  Fly    50 ALDRLHAGLFTNYDSDVQPVFQGT--PTNVSLEMV-VTYIDIDELNGKLTTHCWLNLRWRDEERV 111
            |.:||.:.:|..|:|.::||...:  |..|...:. |..|::||.|..:.|:.|..::|.|.:..
 Worm    25 AEERLLSYIFDGYNSLIRPVLNASSPPIEVFFSLAFVLLINVDEKNQIMQTNVWPTMKWNDYQMQ 89

  Fly   112 WQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAE--TQVTLSHDGHFRWMPPAVYTAYCELN 174
            |.|.::|.|..|.:...:||.|.|.|||..:|..:..  :.|.:.|.|...|:|||||.:.|.::
 Worm    90 WDPREFDGIKTIRVPPDKVWLPDIVLFNNADGNYLVSFYSNVVVEHTGDMLWVPPAVYKSSCLID 154

  Fly   175 MLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESL-----------DHDDLVQSPEWEIVDSRAH 228
            :..:|.|:|.|.|..|||          |.|.:.|           :.:|.:.|..|:::|:...
 Worm   155 VEFFPFDEQVCSLTFGSW----------TFRKDELQLSYLSGKRHVELNDYLPSGVWDLIDAPGL 209

  Fly   229 FVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAA 293
            .:  |....:.|.:..:|::..||.::..|...:..|::..|:||.. ..|||.:...:::.:..
 Worm   210 LI--DERSKISYQIKIRRKALFYTVILIMPTVLMAFLSMMVFYLPAE-SSEKITLAISILLALVV 271

  Fly   294 FLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL------------------------ 334
            ||:..:::||..|:..||:..:...:.:...::.:|.|:::
 Worm   272 FLLVVSKILPPTSSTIPLMAKYLLMTFIMNMITIMVSVIIINVYFRGPATHIMPNWVKTVFLKFL 336

  Fly   335 --------------YLATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPY 385
                          .||..|.::|...:::..|.         :.|.......:|:.|:......
 Worm   337 PVLFVMRRPESTEKELAKMKREKRERRSMKSALK---------TFFKRNDAKISEQPKQTSRKDG 392

  Fly   386 EEADEQESSP----------LGINHTEVPGAKANQFDWALLATAVDRISFVSFSLAFLILAI 437
            ..::|:.||.          :..:.|.....|..:.:|..::..:||:      |.:|..|:
 Worm   393 SSSEEKLSSDAKKAIEAIEYITTHLTHDNAFKRQREEWKFVSVVIDRL------LLYLFFAV 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	97/450 (22%)
		Neur_chan_LBD	52..247	CDD:280998	58/210 (28%)
		Neur_chan_memb	255..434	CDD:280999	34/226 (15%)
acr-3	NP_509129.1	LIC	5..460	CDD:273305	98/452 (22%)
		Neur_chan_LBD	26..226	CDD:280998	58/211 (27%)
		Neur_chan_memb	234..456	CDD:280999	36/231 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810