DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta3 and des-2

DIOPT Version :9

Sequence 1:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_001380111.1 Gene:des-2 / 179574 WormBaseID:WBGene00000955 Length:559 Species:Caenorhabditis elegans


Alignment Length:553 Identity:116/553 - (20%)
Similarity:199/553 - (35%) Gaps:158/553 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 MLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGT-PTNVSLEM-VVTYIDI 88
            ||::..:.:...||:....:..|....||...|..|||...:|::..: |.|||..| :...:::
 Worm     1 MLIIIQSLLLATTASLCIADTPVPTQIRLVHDLLDNYDKKAKPMWDNSKPINVSFSMDLYQILEL 65

  Fly    89 DELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNG-----DEGGLMAE 148
            :|....:..:.|:..||.||...|.|..|:|||::.|....:|.|..||:|.     |:...:..
 Worm    66 NEPQQYILLNAWIIERWFDEFLYWNPDDYENITELRLPYDSIWLPDTTLYNSLVMKDDDTRRLLN 130

  Fly   149 TQVTLSHDGHFR-----WMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGES 208
            :::|.  |.|.|     .:.|.:|...|.|::..:|.|.|.|.:...||          |...:.
 Worm   131 SKLTT--DTHRRAALIELLYPTIYKFSCLLDLRFFPFDVQVCTMTFSSW----------TYDQKG 183

  Fly   209 LDH---------DDLVQSPEWEIVDSRAHFVSQDY------YGYMEYTLTAQRRSSMYTAVIYTP 258
            :|:         .:.:::..|.|:.::.......|      |..::.||..:|:...|...:..|
 Worm   184 IDYFPYSDKIGTSNYLENEGWYILQTKIKRQEVKYACCPNNYTLLQLTLYLRRKPLFYLVNLIIP 248

  Fly   259 ASCIVILALSAFWLPPHMGG---EKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSL 320
            .|.|.::|:..|:......|   ||:.:....::.::..::..:..:|..|...||:..|....:
 Worm   249 TSIITLIAIVGFFTTSSASGMREEKVSLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILAMI 313

  Fly   321 LYLSVSTI--------------------------------------------------------V 329
            :.:|:.|:                                                        |
 Worm   314 IVISLGTVVSSVIIAIQKRGSLGERMSKRALKFAKVLAWFTCTSLPPHVEKEHMMEAFDAPTPLV 378

  Fly   330 EVLVLYLATGKHKRR---LPEALRKLLHGHLGTWLLLSVFSTTGESQAEKT-KEMDEHPYEEADE 390
            ||..|.||:.|...|   :..|.|....|:.|. .|:|..||........| .:.||.....|..
 Worm   379 EVRPLQLASVKESVRNKWVSGARRATQRGNSGL-ALISDKSTDPLIHLSPTAHQPDESISPSAPP 442

  Fly   391 -QESSPL--------------------------------------------GINHTEV--PGAKA 408
             ..||||                                            |::.:.:  ...||
 Worm   443 VPSSSPLPPPLTPGPADDVVSVASELSSKFLTSRMRPKSQKDNTFAAMQRAGLSRSSMRQGSIKA 507

  Fly   409 N------QFDWALLATAVDRISFVSFSLAFLIL 435
            |      :|:|  .||.|:|..||.|.:||||:
 Worm   508 NRQLAVAEFEW--FATVVERTCFVIFVVAFLII 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta3NP_525098.1 LIC 39..437 CDD:273305 113/540 (21%)
Neur_chan_LBD 52..247 CDD:280998 53/221 (24%)
Neur_chan_memb 255..434 CDD:280999 54/294 (18%)
des-2NP_001380111.1 Neur_chan_LBD 28..222 CDD:397192 50/205 (24%)
LGIC_TM_cation 239..>332 CDD:349853 16/92 (17%)
TM1 helix 243..263 CDD:349853 5/19 (26%)
TM2 helix 275..296 CDD:349853 0/20 (0%)
TM3 helix 307..329 CDD:349853 3/21 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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