Protein Alignment nAChRbeta3 and lgc-26

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_503167.1
• Gene: lgc-26 / 178554
• WormBaseID: WBGene00021981
• Length: 486
• Species: Caenorhabditis elegans
• Alignment Length: 444
• Identity: 110/444 - (24%)
• Similarity: 185/444 - (41%)
• Gaps: 105/444 - (23%)

  Fly    26 MLLMGLTSVPGATATADPKNANVKALD--RLHAGLFTNYDSDVQPV-FQGTPTNVSLEMVVTYID 87
            |:|:.|.|: |........||..::.|  :|.|.|...|:|.|:|| .:.|.|.|::.:.:.:::
 Worm     1 MILLRLISI-GVLINFHFGNAASQSTDERKLEAQLLKGYNSKVRPVKVESTVTQVAVYLNIAHVE 64

  Fly    88 -IDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQV 151
             :||.......|..|...|.||...|: .:..||:.:::.||::|.|.:.|:|...|.
 Worm    65 KVDEHEQTALVHGHLMASWTDEYLKWE-RKATNISTLSIASSKLWQPALQLYNSARGN------- 121

  Fly   152 TLSHDGHFRWMPPAVYT-------------AYCELNMLNWPHDKQSCKLKIGSW--GL-KVVLPE 200
              |...:...:|..||.             ..|:.:..|||:|:|||.:.|..|  || :|.|.:
 Worm   122 --SWSLYLTGLPAIVYNTGKVWSRGTFSFFVTCQFDFTNWPYDQQSCPIVITDWVYGLGQVNLSD 184

  Fly   201 NGTARGES-----LDHDDLVQSPE-----WEIVDS-RAHFV-------------SQD-YYGYMEY 240
            ..||.|..     |.:|.:.::.:     ||::|| :.|..             :.| |:..:|:
 Worm   185 PATAAGYGKPTIRLSYDPIDETNKRHVGGWEVIDSWKKHCYWGPKGCLDAEPDGNPDWYWSLLEF 249

  Fly   241 TLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIV-IAAFLMYFAQLL-- 302
            .:|.:|....::..|..|.....::.|..||:      |....|..||.: ||....|.:.:|
 Worm   250 GITLKRHLPYFSLTIVMPMVSTSLMILLGFWI------ENFDFNVFLITLNIALQATYGSNILSR 308

  Fly   303 -PVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKRRLP------------EALRKLLH 354
             |..|..||.:|..||..||..:...::.|:..:|     :.|||            |..:|
 Worm   309 MPPGSGRTPKIVHLYSIGLLISAFQVVLIVMSNFL-----RVRLPSHYEFDFGYDITEIPKK--- 365

  Fly   355 GHLGTWLLLSVFSTTGES--------QAEKTKEMDEHPYEEADEQESSPLGINH 400
                 :.|...|:|.|.|        .|:.|.|      .|..::.|:.:||::
 Worm   366 -----FGLTRFFTTKGLSFDPQELLNPAQLTSE------AEIQKEASTSIGISN 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	105/431 (24%)
		Neur_chan_LBD	52..247	CDD:280998	61/239 (26%)
		Neur_chan_memb	255..434	CDD:280999	41/170 (24%)
lgc-26	NP_503167.1	LGIC_ECD_cation	52..256	CDD:349790	51/213 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870