Protein Alignment nAChRbeta3 and cup-4

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_498710.2
• Gene: cup-4 / 176104
• WormBaseID: WBGene00000845
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 350
• Identity: 78/350 - (22%)
• Similarity: 132/350 - (37%)
• Gaps: 73/350 - (20%)

  Fly    54 LHAGLFTNYDSDVQPVFQGT-PTNVSLEMVVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQY 117
            |...:|..|:...:|:...: ||.|.:...:.::.|::....:|.|..:.:||.||..||.|..:
 Worm    51 LEQKIFRGYNPKNRPMKNASFPTIVDVHWHIIHVSINQREQTMTVHGHIYMRWFDEFLVWDPKDF 115

  Fly   118 DNITQITLKSSEVWTPQITLFNGDEG-----GLMAETQVTLSHDGHFR----WMPPAVYTAYCEL 173
            :||....:|..:||.|:|.:.|...|     .......|.:...|..|    ..|.......|..
 Worm   116 NNIQYARVKKWQVWQPKIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMYPTFSIKVGCAF 180

  Fly   174 NMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLDHDDLVQSPE-----WE-------IVDSR 226
            :..::|:|...|.:.:.|           |:....:...:|...|.     ||       |.|.:
 Worm   181 DFTDYPYDLNKCAINLFS-----------TSTMADVQLQNLYAIPPTLSFGWEEQKMKRIISDFK 234

  Fly   227 AHFVSQD--YY------------GY--------MEYTLTAQRRSSMYTAVIYTPASCIVILALSA 269
            ...||..  ||            |:        :..|::..|.|.::.|.:.||  |||:.:|.:
 Worm   235 IQNVSSSALYYTNGNITSSAPITGFDLGSTWSMLAVTVSFVRHSPLFEAAVVTP--CIVVASLIS 297

  Fly   270 FWLPPHMGGEKIMINGLLIIVIAAFLMYFAQL--LPVLSNNTPLVV--IFYSTSLLYLSVSTIVE 330
            .         ...|:.|....:...|.::.||  |..|....||.|  |.:...|:.:.:.|...
 Worm   298 M---------TFFIDSLSSTFLLMMLHFYVQLIFLHDLVEKLPLSVSEIPFCIKLIGILMYTNGL 353

  Fly   331 VLVLY---LATGKHKRRLPEALRKL 352
            .|||:   |....:|..:|:.|.|:
 Worm   354 TLVLHSSLLCGSYYKCPVPQQLNKI 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	78/349 (22%)
		Neur_chan_LBD	52..247	CDD:280998	48/236 (20%)
		Neur_chan_memb	255..434	CDD:280999	27/104 (26%)
cup-4	NP_498710.2	Neur_chan_LBD	48..>222	CDD:280998	38/181 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910