Protein Alignment nAChRbeta3 and acr-7

DIOPT Version :10

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_495647.1
• Gene: acr-7 / 174262
• WormBaseID: WBGene00000046
• Length: 538
• Species: Caenorhabditis elegans
• Alignment Length: 541
• Identity: 114/541 - (21%)
• Similarity: 198/541 - (36%)
• Gaps: 149/541 - (27%)

  Fly    20 LQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEMVVT 84
            :|:::.:.|..|....|.|.....|.|      :|:..|.|||...|:||     .|....:.||
 Worm     6 IQIVLPVALFFLIVFNGFTVEGSKKEA------QLYRDLLTNYSYLVRPV-----RNPKKALTVT 59

  Fly    85 ---YID----IDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLK-SSEVWTPQITLFN-- 139
               :|.    :|..:..:..:.||...|.|....|.|..|:|||.:..: ..::|.|.|.|:|
 Worm    60 MKVFIQQVLLVDAKHQMIEVNAWLKYIWTDFRLRWNPLDYENITSVRFQGEDQIWQPDILLYNRY 124

  Fly   140 -GDEG---GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVV 197
             .||.   .:..:|......||...|:||.::...|::::..:|.|:|.|.:|.|||   |..:.
 Worm   125 IEDEQESFDITYKTNAVAYSDGVINWIPPGIFKLSCKMDITLFPFDEQICFMKFGSWTYHGFALD 189

  Fly   198 LPENGTARGE--SLDHDDLVQSPEWEIVDSRAHFVSQDY------YGYMEYTLTAQRRSSMYTAV 254
            | .....:|:  |.|....:.:.||.::.:.|....:.|      |..:::.|..:||:..|...
 Worm   190 L-RLDVVKGQEPSADLSTYITNGEWHLLSAPARREEKFYKCCKEPYPTVKFYLHLRRRTFYYVFN 253

  Fly   255 IYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTS 319
            :..|...:..::|.||.||.....|||.:...:::.:..||...:::.|..|...||:.:|:|..
 Worm   254 VVLPTLLVSFMSLLAFCLPATDLSEKIGLQTTILLSVCFFLTILSEMTPTTSEAVPLLGVFFSAL 318

  Fly   320 LLYLSVSTIVEVLVLYLATGKHKRRLPEALRKLLHGHLG-----------TWLLL---------- 363
            ...:::||...:|||.:           ..|::.:.:|.           .||::
 Worm   319 TFIVAMSTTFTILVLNI-----------RYRQITNHYLSPMFRSIFLECLPWLMMMKRPDHKFRR 372

  Fly   364 ----------------------SVFSTTGESQAEKTKEMDEHP---------------------- 384
                                  |:...|...|..:|......|
 Worm   373 GSSYRDSSADQCVQCAKNAELKSILRGTDNQQQIETNTFYPFPTETLSLNRKVGDGLFIQRRCQI 437

  Fly   385 YEEADEQE--------SSPLGINHTEVPG----------------------------AKANQFDW 413
            :|||..::        ...|..|.:|:..                            .|..|.:|
 Worm   438 HEEARSEKFTHGMLACEKSLRENGSELANILVTILKMYEVMVSQVERIRKRIALKRKRKDIQDEW 502

  Fly   414 ALLATAVDRISFVSFSLAFLI 434
            ...|.||||...:.|::.|:|
 Worm   503 KFAAQAVDRFCLIIFTIVFII 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	109/522 (21%)
acr-7	NP_495647.1	LIC	28..524	CDD:455710	109/519 (21%)
		LGIC_ECD_nAChR	56..246	CDD:349798	47/190 (25%)
		Cys-loop	160..174	CDD:349798	4/13 (31%)