Protein Alignment nAChRbeta3 and unc-38

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_491472.1
• Gene: unc-38 / 172105
• WormBaseID: WBGene00006774
• Length: 511
• Species: Caenorhabditis elegans
• Alignment Length: 495
• Identity: 110/495 - (22%)
• Similarity: 197/495 - (39%)
• Gaps: 114/495 - (23%)

  Fly    26 MLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQP-VFQGTPTNVSLEMVVT-YIDI 88
            :||..::.:.......|.|        ||:..|..||:...:| .....|..:.|::.:: .||:
 Worm    10 LLLFCISFIKLTEGNEDAK--------RLYDDLMVNYNRHRRPSTSPNKPLTIKLKLRLSQIIDV 66

  Fly    89 DELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG--GLMAETQV 151
            .|::..:|...||...|.|.:..|.|..|..:..:.:....:|.|.|.|:|..:.  .:...|:.
 Worm    67 HEIDQIMTCSVWLKQTWIDRKLSWDPVNYGGVNVLYVPYEMIWVPDIVLYNNADSNYNITISTKA 131

  Fly   152 TLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWG-----LKVVLPE----------- 200
            ||.:.|...|.|||::.:.|::::..:|.|:|.|.||.|||.     |.|.|.|
 Worm   132 TLHYTGEVTWEPPAIFKSMCQIDVRWFPFDEQQCHLKFGSWTFSENLLSVELNEPSLRYEEEIDE 196

  Fly   201 -----NGTARGESLDHDDLVQSPEWEIVDSRAHFVSQDY--------YGYMEYTLTAQRRSSMYT 252
                 |.|...:.:|..|...|.||:|:...|...:::|        |..:.|.|..:|:...||
 Worm   197 KGIIDNVTVAEDGIDLSDYYPSVEWDIMSRVAKRRAKNYPSCCPQSAYIDVTYYLQLRRKPLFYT 261

  Fly   253 AVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYS 317
            ..:..|...|..|.:..|:||.. .|||:.:...:::.:..|.:...:::|..|...||:..:..
 Worm   262 VNLVFPCVGISFLTILVFYLPSD-SGEKVTLCISILVALTIFFLLLTEIIPATSITLPLIGKYLL 325

  Fly   318 TSLLYLSVSTIVEVLVLYLATGKHKRR-----LPEALRKLLHGHLGTWLLLSVFSTTGESQAEKT 377
            .:::.:::|.:|.|:.|.|    |.|.     :|..::|:..    .||...:|         ..
 Worm   326 FTMVMVTLSVVVTVISLNL----HFRTPTTHLMPNWVKKVFL----KWLPKLLF---------MR 373

  Fly   378 KEMDEHPYEEADEQESSP----------------LGIN-------------HTEVPGAKANQ--- 410
            :.:|:  |||..:.:..|                :|.|             :...|..||.:
 Worm   374 RPIDD--YEEKFDDKKKPKDGKIALSVHAHRVSNVGNNIRNATIDDTIQKMYYSPPVVKAFENIC 436

  Fly   411 ----------------FDWALLATAVDRISFVSFSLAFLI 434
                            .||..:|..:||:..:.||:|..:
 Worm   437 FIAELLKKKDRDDKIDEDWKYVAMVLDRLFLLIFSIACFV 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	108/482 (22%)
		Neur_chan_LBD	52..247	CDD:280998	59/227 (26%)
		Neur_chan_memb	255..434	CDD:280999	44/231 (19%)
unc-38	NP_491472.1	Neur_chan_LBD	27..257	CDD:280998	61/237 (26%)
		LIC	29..483	CDD:273305	106/468 (23%)
		Neur_chan_memb	264..481	CDD:280999	44/233 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910