DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta3 and Chrna2

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_596911.1	Gene:	Chrna2 / 170945	RGDID:	621533	Length:	511	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	126/515 - (24%)
Similarity:	220/515 - (42%)	Gaps:	128/515 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEMVVT 84
            ||....:.|..|..||   |....:.::..|.|||...||..|:...:||     .|.|..::|.
  Rat     8 LQFWTHLYLWCLLLVP---AVLTQQGSHTHAEDRLFKHLFGGYNRWARPV-----PNTSDVVIVR 64

  Fly    85 Y-------IDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDE 142
            :       ||:||.|..:||:.||...|.|.:..|.|:::.|:|.:.:.|..:|.|.|.|:|..:
  Rat    65 FGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNAD 129

  Fly   143 GGLMAETQVTLSH---DGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPEN 201
            |. .|.|.:|.:|   .|...|:|||:|.:.|.:::..:|.|:|:||:|.|||   ..|:.|.:
  Rat   130 GE-FAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQ- 192

  Fly   202 GTARGESLDHDDLVQSPEWEIVDSRAHFVSQDY------YGYMEYTLTAQRRSSMYTAVIYTPAS 260
               ...::|..|..:|.||.|:::...:.|:.|      |..:.|....:|....||..:..|..
  Rat   193 ---MERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCL 254

  Fly   261 CIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSV 325
            .|..|.:..|:||... ||||.:...:::.:..||:...:::|..|...||:..:...:::::::
  Rat   255 LISCLTVLVFYLPSEC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTL 318

  Fly   326 STIVEVLVLYLATGKHKR-----RLPEALRKLLHGHLGTWLLLS--------------------- 364
            |.::.|.||.:    |.|     .:|..:|..|.|.:..||:::
  Rat   319 SIVITVFVLNV----HHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYH 379

  Fly   365 -VFSTTGESQAEKTKEMDEHPYEEADEQES---------SPLGINH-------------TEVPGA 406
             :.:.....:.|:|:|      ||.:|.|:         |.:|:.:             |:.| :
  Rat   380 WLETNMDAGEREETEE------EEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTP-S 437

  Fly   407 KANQF-------------------------------DWALLATAVDRISFVSFSLAFLIL 435
            :|::.                               ||..:|..||||    |...|:|:
  Rat   438 QASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRI----FLWLFIIV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	120/496 (24%)
		Neur_chan_LBD	52..247	CDD:280998	65/213 (31%)
		Neur_chan_memb	255..434	CDD:280999	49/258 (19%)
Chrna2	NP_596911.1	LIC	35..504	CDD:273305	119/485 (25%)
Chrna2	NP_596911.1	LGIC_ECD_nAChR_A2	36..242	CDD:349816	66/215 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810