Protein Alignment nAChRbeta3 and CHRNE

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 126/494 - (25%)
• Similarity: 198/494 - (40%)
• Gaps: 100/494 - (20%)

  Fly    17 PLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM 81
            ||.:.:|:|:|..|:           .||..:    ||:..||.|||...:||.:...| |::.:
Human     5 PLGVLLLLGLLGRGV-----------GKNEEL----RLYHHLFNNYDPGSRPVREPEDT-VTISL 53

  Fly    82 VVTYIDIDELNGK---LTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG 143
            .||..::..||.|   |||..|:.:.|:|....:....:..|..:.:.|..||.|:|.|.|..:|
Human    54 KVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDG 118

  Fly   144 --GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLK--------VVL 198
              |:..:..|.:...|...|:|||:|.:.|.:.:..:|.|.|:|.|...|....        .|.
Human   119 QFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVD 183

  Fly   199 PENGTARGESLDHDDLVQSPEWEI-----VDSRAHFVSQDYYGYME--YTLTAQRRSSMYTAVIY 256
            .:..|.....:|.:...::.||.|     |..|.|..:.|..|..:  |:|..:|:...|...|.
Human   184 NDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINII 248

  Fly   257 TPASCIVI--LALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTS 319
            .|  |::|  |.|.|::||...||:|..::..:::....||...||.:|..|.:.||:..|.
Human   249 VP--CVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFL--- 308

  Fly   320 LLYLSVSTIVE---VLVLYLA-----TGKHKRRLPEALRKLLHGHLGT----------------- 359
            :..:.|:|::.   |:||.::     |.....||...|.:||...||:
Human   309 IFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRAS 373

  Fly   360 --WLLLS-------------VFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHT-------E 402
              .|||.             ||......|...|....:.....|.|.......:|..       |
Human   374 SVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQE 438

  Fly   403 VPGAKANQFDWALLATAVDRISF--------VSFSLAFL 433
            ..|.:.:  ||..:..|:|.|.|        |..||.||
Human   439 ATGEEVS--DWVRMGNALDNICFWAALVLFSVGSSLIFL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	120/472 (25%)
		Neur_chan_LBD	52..247	CDD:280998	59/214 (28%)
		Neur_chan_memb	255..434	CDD:280999	57/236 (24%)
CHRNE	NP_000071.1	LIC	21..475	CDD:273305	118/465 (25%)
		Neur_chan_LBD	24..240	CDD:280998	60/220 (27%)
		Neur_chan_memb	247..474	CDD:280999	55/233 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910