Protein Alignment nAChRbeta3 and CHRNE

DIOPT Version :10

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 126/494 - (25%)
• Similarity: 198/494 - (40%)
• Gaps: 100/494 - (20%)

  Fly    17 PLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM 81
            ||.:.:|:|:|..|:           .||..:    ||:..||.|||...:||.:...| |::.:
Human     5 PLGVLLLLGLLGRGV-----------GKNEEL----RLYHHLFNNYDPGSRPVREPEDT-VTISL 53

  Fly    82 VVTYIDIDELNGK---LTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG 143
            .||..::..||.|   |||..|:.:.|:|....:....:..|..:.:.|..||.|:|.|.|..:|
Human    54 KVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDG 118

  Fly   144 --GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLK--------VVL 198
              |:..:..|.:...|...|:|||:|.:.|.:.:..:|.|.|:|.|...|....        .|.
Human   119 QFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVD 183

  Fly   199 PENGTARGESLDHDDLVQSPEWEI-----VDSRAHFVSQDYYGYME--YTLTAQRRSSMYTAVIY 256
            .:..|.....:|.:...::.||.|     |..|.|..:.|..|..:  |:|..:|:...|...|.
Human   184 NDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINII 248

  Fly   257 TPASCIVI--LALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTS 319
            .|  |::|  |.|.|::||...||:|..::..:::....||...||.:|..|.:.||:..|.
Human   249 VP--CVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFL--- 308

  Fly   320 LLYLSVSTIVE---VLVLYLA-----TGKHKRRLPEALRKLLHGHLGT----------------- 359
            :..:.|:|::.   |:||.::     |.....||...|.:||...||:
Human   309 IFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRAS 373

  Fly   360 --WLLLS-------------VFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHT-------E 402
              .|||.             ||......|...|....:.....|.|.......:|..       |
Human   374 SVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQE 438

  Fly   403 VPGAKANQFDWALLATAVDRISF--------VSFSLAFL 433
            ..|.:.:  ||..:..|:|.|.|        |..||.||
Human   439 ATGEEVS--DWVRMGNALDNICFWAALVLFSVGSSLIFL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	120/472 (25%)
CHRNE	NP_000071.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	49/189 (26%)
		Cys-loop	148..162	CDD:349831	4/13 (31%)
		Neur_chan_memb	247..474	CDD:460753	55/233 (24%)