DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta3 and Chrng

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	XP_006529141.1	Gene:	Chrng / 11449	MGIID:	87895	Length:	541	Species:	Mus musculus

Alignment Length:	520	Identity:	128/520 - (24%)
Similarity:	209/520 - (40%)	Gaps:	103/520 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTTPKIKAPVSGPGL---PLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNY 62
            :|.|....:.:..|.|   ||.|.:|.       :..|.:.|.|..:|..    :||.|.|..||
Mouse     6 VTCTLPSPSTLPAPSLHLIPLCLLLLW-------SEPPPSVAGAQSRNQE----ERLLADLMRNY 59

  Fly    63 DSDVQPVFQGTP-TNVSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITL 125
            |..::|..:.:. .||||::.:| .|.::|....|||:.|:.::|.|....|.|..|:.:..:.:
Mouse    60 DPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPKDYEGLWILRV 124

  Fly   126 KSSEVWTPQITLFNGDEG--GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLK 188
            .|:.||.|.|.|.|..:|  .:.....|.:|.||...|:|||::.:.|.:::..:|.|.|:|.|.
Mouse   125 PSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVTYFPFDWQNCSLV 189

  Fly   189 IGSWGLKV------VLPENGTA-RGESLDHDDLVQSPEWEI--------VDSRAHFVSQDYYGYM 238
            ..|.....      :..|:|.| ....:|.:...::.||.|        :||.|......:...:
Mouse   190 FQSQTYSTSEINLQLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLLDSVAPAEEAGHQKVV 254

  Fly   239 EYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLP 303
            .| |..||:...|...|..|...|..:|:..::||...||:|..:...:::....||...|:.:|
Mouse   255 FY-LLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVATNVLLAQTVFLFLVAKKVP 318

  Fly   304 VLSNNTPLVVIFYSTSLLYLSVSTIV----EVLVL----------YLATGKHK---RRLPEALR- 350
            ..|...||:    |..|.:|.|.||:    .|:||          .:|.|..|   |.||:.||
Mouse   319 ETSQAVPLI----SKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM 379

  Fly   351 ---------------KLLHGHLGTW----------------LLLSVFSTTGESQAEKTKEMDEHP 384
                           :|.:|....|                ||.......|..||...|..:...
Mouse   380 HVRPLAPAAVQDARFRLQNGSSSGWPIMAREEGDLCLPRSELLFRQRQRNGLVQAVLEKLENGPE 444

  Fly   385 YEEADE-----QESSPL------GINHTEVPGAKANQFD-----WALLATAVDRISFVSFSLAFL 433
            ..::.|     :::||.      ..|.......:.:.||     |.|:...:||:.|::....|:
Mouse   445 VRQSQEFCGSLKQASPAIQACVDACNLMARARRQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFI 509

Fly 434 433
Mouse 510 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	119/479 (25%)
		Neur_chan_LBD	52..247	CDD:280998	60/213 (28%)
		Neur_chan_memb	255..434	CDD:280999	54/244 (22%)
Chrng	XP_006529141.1	LGIC_ECD_nAChR_G	71..263	CDD:349830	53/192 (28%)
Chrng	XP_006529141.1	Neur_chan_memb	270..515	CDD:367256	54/244 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810