Protein Alignment nAChRbeta3 and Chrna7

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_031416.3
• Gene: Chrna7 / 11441
• MGIID: 99779
• Length: 502
• Species: Mus musculus
• Alignment Length: 464
• Identity: 107/464 - (23%)
• Similarity: 194/464 - (41%)
• Gaps: 86/464 - (18%)

  Fly    53 RLHAGLFTNYDSDVQPVFQGT-PTNVSLEM-VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPS 115
            ||:..|..||:...:||...: |..|...: ::..:|:||.|..|||:.||.:.|.|....|..|
Mouse    28 RLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMS 92

  Fly   116 QYDNITQITLKSSEVWTPQITLFNGDEGGLMA--ETQVTLSHDGHFRWMPPAVYTAYCELNMLNW 178
            :|..:..:.....::|.|.|.|:|..:....|  .|.|.::..||.:::||.::.:.|.:::..:
Mouse    93 EYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWF 157

  Fly   179 PHDKQSCKLKIGSW---GLKVVLPENGTARGESLDHDDLVQSPEWEIV------DSRAHFVSQDY 234
            |.|.|.||||.|||   |..:.|      :.:..|....:.:.||:::      :.:.:...::.
Mouse   158 PFDVQQCKLKFGSWSYGGWSLDL------QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEP 216

  Fly   235 YGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFA 299
            |..:.||:|.:||:..|...:..|...|..|||..|.||.. .||||.:...:::.:..|::..|
Mouse   217 YPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLLVA 280

  Fly   300 QLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL-YLATGKHKRRLPEALRKLLHGHLGTWL-- 361
            :::|..|::.||:..:::::::.:.:|.:|.|:|| |........::|:..|.:|......:|
Mouse   281 EIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRM 345

  Fly   362 --------------------LLSVFSTTGESQAEKTKEM-------------------------- 380
                                |.||..:.|.........:
Mouse   346 KRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRL 410

  Fly   381 ------DEHPYEEADEQESSPLGINHTEVPGAKANQF-----------DWALLATAVDRISFVSF 428
                  |||........:..|......|.....||:|           :|...|..|||:..::|
Mouse   411 ACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAF 475

  Fly   429 SLAFLILAI 437
            |:..:|..|
Mouse   476 SVFTIICTI 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	106/462 (23%)
		Neur_chan_LBD	52..247	CDD:280998	55/206 (27%)
		Neur_chan_memb	255..434	CDD:280999	47/244 (19%)
Chrna7	NP_031416.3	LIC	4..490	CDD:273305	107/464 (23%)
		Neur_chan_LBD	26..230	CDD:280998	56/207 (27%)
		Neur_chan_memb	237..486	CDD:280999	49/249 (20%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000269|PubMed:32783947	260..267		3/6 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910