Protein Alignment nAChRbeta3 and Chrna6

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_067344.2
• Gene: Chrna6 / 11440
• MGIID: 106213
• Length: 494
• Species: Mus musculus
• Alignment Length: 462
• Identity: 112/462 - (24%)
• Similarity: 196/462 - (42%)
• Gaps: 96/462 - (20%)

  Fly    52 DRLHAGLFTNYDSDVQPVFQ-GTPTNVSLEMVVTYI-DIDELNGKLTTHCWLNLRWRDEERVWQP 114
            ::|...||.:|:..::||.. ..|..|..|:.:|.: ::||:|..:.|:.||...|:|....|.|
Mouse    35 EQLFHRLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHIWKDYRLRWDP 99

  Fly   115 SQYDNITQITLKSSEVWTPQITLFNGDEGGLMAE--TQVTLSHDGHFRWMPPAVYTAYCELNMLN 177
            ::||.|..:.:.:..:|.|.|.|:|...|....|  |:..|.:||...|.|||::.:.|.:::..
Mouse   100 TEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITF 164

  Fly   178 WPHDKQSCKLKIGSW-------GLKVVLPENGTARGESLDHDDLVQSPEWEIVDSRA--HFVS-- 231
            :|.|.|:|.||.|||       .|.::        |..:|.:|..::.||||||:..  |.:.
Mouse   165 FPFDHQNCSLKFGSWTYDKAEIDLLII--------GSKVDMNDFWENSEWEIVDASGYKHDIKYN 221

  Fly   232 --QDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAF 294
              ::.|..:.|:...:|....||..:..|...|..|.:..|:||... |||:.:...:::.:..|
Mouse   222 CCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVF 285

  Fly   295 LMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL---YLATGKHKRRLPEALRKLLHGH 356
            |:...:.:|..|...|||..:...:::::::|.:|.|.||   |.....|  .:|:.::.:....
Mouse   286 LLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATH--TMPKWVKTIFLQA 348

  Fly   357 LGTWLLLS-------------------------VFSTTGESQ----------------------- 373
            ..:.|::.                         .|:..|||:
Mouse   349 FPSILMMRKPLDKTKEAGGVKDPKSHTKRPAKVKFTHRGESKLLKECHHCQKSSDIAPGKRRSSQ 413

  Fly   374 --AEKTKEMDEHPYEEADEQESSPLGI----NHTEVPGAKANQF--DWALLATAVDRISFVSFSL 430
              |....|..||..:..|..||.....    :|.|     .|:.  ||..:|..|||:    |..
Mouse   414 QPARWVAENSEHSSDVEDVIESVQFIAENMKSHNE-----TNEVEDDWKYMAMVVDRV----FLW 469

  Fly   431 AFLILAI 437
            .|:|:.:
Mouse   470 VFIIVCV 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	112/460 (24%)
		Neur_chan_LBD	52..247	CDD:280998	61/211 (29%)
		Neur_chan_memb	255..434	CDD:280999	47/237 (20%)
Chrna6	NP_067344.2	LIC	15..484	CDD:273305	112/462 (24%)
		Neur_chan_LBD	34..240	CDD:280998	62/212 (29%)
		Neur_chan_memb	247..483	CDD:280999	48/242 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..423		2/23 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910