Protein Alignment nAChRbeta3 and CHRNB4

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_000741.1
• Gene: CHRNB4 / 1143
• HGNCID: 1964
• Length: 498
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 106/470 - (22%)
• Similarity: 186/470 - (39%)
• Gaps: 100/470 - (21%)

  Fly    45 NANVKALDRLHAGLFTNYDSDVQPVFQGTP-TNVSLEM-VVTYIDIDELNGKLTTHCWLNLRWRD 107
            ||..|.:|.|...  |.|::.::|....:. .::.|:: :...|.::|....:||:.||...|.|
Human    25 NAEEKLMDDLLNK--TRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTD 87

  Fly   108 EERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG--GLMAETQVTLSHDGHFRWMPPAVYTAY 170
            ....|..|:|:.:..:.:.:..:|.|.|.|:|..:|  .:...|.:.:..:|...|:|||:|.:.
Human    88 YRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSA 152

  Fly   171 CELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLDH--------------DDLVQSPEWE 221
            |::.:..:|.|:|:|.||..||               :.||              ||...|.||:
Human   153 CKIEVKYFPFDQQNCTLKFRSW---------------TYDHTEIDMVLMTPTASMDDFTPSGEWD 202

  Fly   222 IV--DSRAHFVSQD-YYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMI 283
            ||  ..|.....|| .|..:.|....:|:...||..:..|.....:||:..|:||... |||:.:
Human   203 IVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDC-GEKMTL 266

  Fly   284 NGLLIIVIAAFLMYFAQLLPVLSNNTPLV--VIFYSTSLLYLSVSTIVEVLVLYLATGKHKRRLP 346
            ...:::.:..||:..::::|..|.:.||:  .:.::..|:..|:.|.|.||.::..:.......|
Human   267 CISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAP 331

  Fly   347 EALRKLLHGHLGTWLLLS----------VF----STTGESQAEKTKEMDEHPY-------EEADE 390
            ...|..|| .|.|:|.:.          .|    |...:.:|..|.....:.|       ..|..
Human   332 WVKRCFLH-KLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA 395

  Fly   391 QESSPLGINHTEVPG----AKANQF-----------------------------DWALLATAVDR 422
            ...||.|.....:|.    ..:.:|                             ||..:|..|||
Human   396 ASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDR 460

  Fly   423 ISFVSFSLAFLILAI 437
            :    |...|:.:.:
Human   461 L----FLWVFMFVCV 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	106/468 (23%)
		Neur_chan_LBD	52..247	CDD:280998	53/215 (25%)
		Neur_chan_memb	255..434	CDD:280999	47/234 (20%)
CHRNB4	NP_000741.1	Neur_chan_LBD	5..480	CDD:332142	106/470 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..377		4/19 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810