Protein Alignment nAChRbeta3 and CHRNB3

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 119/457 - (26%)
• Similarity: 208/457 - (45%)
• Gaps: 60/457 - (13%)

  Fly    26 MLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT-YIDI 88
            ||::.:..:|.:..|.  .|:..:..|.|...||..|...|:||.....| .|...:.:: .:|:
Human     6 MLVLIVLGIPSSATTG--FNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDV 68

  Fly    89 DELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLF-NGD---EGGLMAET 149
            ||.|..:||:.||...|.|.:..|.|..|..|..|.:.|..:|.|.|.|| |.|   ||.||  |
Human    69 DEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLM--T 131

  Fly   150 QVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGESLDH 211
            :|.:..:|...|.|||.|.:.|.:::..:|.|:|:|.:|.|||   |..|.|    ....|::|.
Human   132 KVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDL----ILINENVDR 192

  Fly   212 DDLVQSPEWEIVDSRAHFVSQD----YYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWL 272
            .|...:.||||::::....::.    .|.::.|:...:|....||..:..|...:..|.:..|:|
Human   193 KDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYL 257

  Fly   273 PPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYL- 336
            |.. .|||:.::..:::.:..||:...:::|..|...||:..:....::::::|.||.|.|:.:
Human   258 PSD-EGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVH 321

  Fly   337 ---ATGKH------KRRLPEALRKLL--HGHLGTWLLLSVFSTTGESQAE---KTKEMDEHPYEE 387
               ::..|      ||...:.|.|||  ..|:..      :|:..:.:::   |.|.:::...::
Human   322 HRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDR------YSSPEKEESQPVVKGKVLEKKKQKQ 380

  Fly   388 ADEQESSPLGINHTEVPG-------AKANQF------DWALLATAVDRISFVSFSLAFLILAIRC 439
            ..:.|...:.........       .|...|      ||..:|..:|||    |...|||:::..
Human   381 LSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRI----FLWLFLIVSVTG 441

  Fly   440 SV 441
            ||
Human   442 SV 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	114/438 (26%)
		Neur_chan_LBD	52..247	CDD:280998	66/207 (32%)
		Neur_chan_memb	255..434	CDD:280999	41/206 (20%)
CHRNB3	NP_000740.1	Neur_chan_LBD	23..449	CDD:332142	115/438 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810