Protein Alignment nAChRbeta3 and CHRNB1

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_000738.2
• Gene: CHRNB1 / 1140
• HGNCID: 1961
• Length: 501
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 117/517 - (22%)
• Similarity: 208/517 - (40%)
• Gaps: 131/517 - (25%)

  Fly    17 PLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQ-GTPTNVSLE 80
            |..|.||:|.|  |....||...:        :|..||...||:.|||.|:|..: |....||:.
Human     3 PGALLMLLGAL--GAPLAPGVRGS--------EAEGRLREKLFSGYDSSVRPAREVGDRVRVSVG 57

  Fly    81 MVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG 144
            :::. .|.::|.:.:::|..:|:|.|.|....|.|:::|.|..:.:.:..||.|.:.|.|.::|.
Human    58 LILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGN 122

  Fly   145 --LMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW-------GLKVVLPE 200
              :..:..|.:|.||..||.||.:|.:.|.:.:..:|.|.|:|.:...|:       .|:..|..
Human   123 FDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGP 187

  Fly   201 NGTARGESLDHD-DLVQSPEWEIVDSRAHFVSQ--DYYGYME-------YTLTAQRRSSMYTAVI 255
            :|....|...|: ..:::.:|||:...:..:..  |..|..|       :.|..:|:...|...:
Human   188 DGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNV 252

  Fly   256 YTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSL 320
            ..|...|.:||:..|:|||. .|||:.::...::.:..||:..|..:|..|.:.|:::.:...::
Human   253 IAPCILITLLAIFVFYLPPD-AGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTM 316

  Fly   321 LYLSVSTIVEVLVLYL-ATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHP 384
            :.::.|.|:.|:||.| ....|..::|..:|::....|..:|.|                  :.|
Human   317 VLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRL------------------KRP 363

  Fly   385 YEEADEQESSPLGINHTEVPGA---------------------KANQF----------------- 411
            ..|.|.....|    |...||:                     |.|:|
Human   364 KPERDLMPEPP----HCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPN 424

  Fly   412 ----------------------------------DWALLATAVDRI---SFVSF-SLAFLIL 435
                                              ||..:|..|||:   :|:.| |:..|::
Human   425 RAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	108/495 (22%)
		Neur_chan_LBD	52..247	CDD:280998	56/215 (26%)
		Neur_chan_memb	255..434	CDD:280999	48/255 (19%)
CHRNB1	NP_000738.2	Neur_chan_LBD	27..245	CDD:308532	57/217 (26%)
		Neur_chan_memb	252..487	CDD:308533	49/258 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810