Protein Alignment nAChRbeta3 and CHRNA2

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_000733.2
• Gene: CHRNA2 / 1135
• HGNCID: 1956
• Length: 529
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 130/529 - (24%)
• Similarity: 218/529 - (41%)
• Gaps: 125/529 - (23%)

  Fly    13 GPGLPLLLQML-MGMLLMGLTSVPGATATADPKNA------------------NVKALDRLHAGL 58
            ||..|:.|... :.:..:.||...|..|...|..|                  :.:..|||...|
Human     2 GPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHL 66

  Fly    59 FTNYDSDVQPVFQGTPTNVSLEMVVTY-------IDIDELNGKLTTHCWLNLRWRDEERVWQPSQ 116
            |..|:...:||     .|.|..::|.:       ||:||.|..:||:.||...|.|.:..|.|:.
Human    67 FRGYNRWARPV-----PNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTD 126

  Fly   117 YDNITQITLKSSEVWTPQITLFNGDEGGLMAETQVTLSH---DGHFRWMPPAVYTAYCELNMLNW 178
            :.|||.:.:.|..:|.|.|.|:|..:|. .|.|.:|.:|   .|...|:|||:|.:.|.:::..:
Human   127 FGNITSLRVPSEMIWIPDIVLYNNADGE-FAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFF 190

  Fly   179 PHDKQSCKLKIGSW---GLKVVLPENGTARGESLDHDDLVQSPEWEIVDSRAHFVSQDY------ 234
            |.|:|:||:|.|||   ..|:.|.:    ..:::|..|..:|.||.||::...:.|:.|
Human   191 PFDQQNCKMKFGSWTYDKAKIDLEQ----MEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEI 251

  Fly   235 YGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFA 299
            |..:.|....:|....||..:..|...|..|.:..|:||... ||||.:...:::.:..||:...
Human   252 YPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDC-GEKITLCISVLLSLTVFLLLIT 315

  Fly   300 QLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKR-----RLPEALRKLLHGHLGT 359
            :::|..|...||:..:...:::::::|.::.|.||.:    |.|     .:|..:|..|.|.:..
Human   316 EIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNV----HHRSPSTHTMPHWVRGALLGCVPR 376

  Fly   360 WLLLS----------------------VFSTTGESQAEKTKEMDEH------------------- 383
            |||::                      :.|.....:.|...|.::.
Human   377 WLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGH 441

  Fly   384 -------PYEEADEQESSPL----------GI----NHTEVPGAKAN-QFDWALLATAVDRISFV 426
                   |..||..||...|          |:    :|.....|.:: :.||..:|..:|||
Human   442 LHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRI--- 503

  Fly   427 SFSLAFLIL 435
             |...|:|:
Human   504 -FLWLFIIV 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	123/502 (25%)
		Neur_chan_LBD	52..247	CDD:280998	67/213 (31%)
		Neur_chan_memb	255..434	CDD:280999	49/246 (20%)
CHRNA2	NP_000733.2	LIC	57..522	CDD:273305	120/474 (25%)
		Neur_chan_LBD	59..265	CDD:280998	68/215 (32%)
		Neur_chan_memb	272..520	CDD:280999	50/249 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810