Protein Alignment nAChRbeta3 and Chrnb4

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_683746.1
• Gene: Chrnb4 / 108015
• MGIID: 87892
• Length: 495
• Species: Mus musculus
• Alignment Length: 518
• Identity: 122/518 - (23%)
• Similarity: 200/518 - (38%)
• Gaps: 141/518 - (27%)

  Fly    15 GLPLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTP-TNVS 78
            |.||||..|..:|      .||....|   ||..|.:|.|...  |.|::.::|....:. .::.
Mouse     3 GTPLLLVSLFALL------QPGDCRLA---NAEEKLMDDLLNK--TRYNNLIRPATSSSQLISIR 56

  Fly    79 LEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDE 142
            ||:.:: .|.::|....:||..||...|.|....|..|.|:.:..:.:.:..||.|.|.|:|..:
Mouse    57 LELSLSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNAD 121

  Fly   143 G--GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTAR 205
            |  .:...|.|.:..:|..:|:|||:|.:.|::.:.::|.|:|:|.||..||
Mouse   122 GTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSW------------- 173

  Fly   206 GESLDH--------------DDLVQSPEWEIV--DSRAHFVSQD-YYGYMEYTLTAQRRSSMYTA 253
              :.||              ||...|.||:||  ..|.....|| .|..:.|....:|:...||.
Mouse   174 --TYDHTEIDMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTI 236

  Fly   254 VIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLV--VIFY 316
            .:..|...|..||:..|:||... |||:.:...:::.:..||:..::::|..|.:.||:  .:.:
Mouse   237 NLIIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLF 300

  Fly   317 STSLLYLSVSTIVEVL-VLYLATGKHK----------RRLPEAL-----------RKLLHG---H 356
            :..|:..|:.|.|.|| |.:.:...|.          .:||..|           .::.|.   |
Mouse   301 TMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSPARVPHSSQLH 365

  Fly   357 LGTWLLLSVFSTTGESQ----------------AEKTKEMDEH---------------------- 383
            |.|....|. |..|.|.                |.....:..|
Mouse   366 LTTAEATST-SALGPSSPSNLYGNSMYFVNPVPATPKSAVSSHTAGLPRDARLRSSGRFRQDLQE 429

  Fly   384 ---------PYEEADEQESSPLGINHTEVPGAKANQFDWALLATAVDRISFVSFSLAFLILAI 437
                     .:.|:|:::.|.:.              ||..:|..|||:    |...|:|:.|
Mouse   430 ALEGVSFIAQHLESDDRDQSVIE--------------DWKFVAMVVDRL----FLWVFVIVCI 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	112/492 (23%)
		Neur_chan_LBD	52..247	CDD:280998	56/215 (26%)
		Neur_chan_memb	255..434	CDD:280999	48/252 (19%)
Chrnb4	NP_683746.1	LIC	21..483	CDD:273305	113/494 (23%)
		Neur_chan_LBD	26..231	CDD:280998	58/221 (26%)
		Neur_chan_memb	238..481	CDD:280999	50/257 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810