Protein Alignment nAChRbeta3 and chrna6

DIOPT Version :10

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: XP_031759256.1
• Gene: chrna6 / 100495287
• XenbaseID: XB-GENE-6033398
• Length: 488
• Species: Xenopus tropicalis
• Alignment Length: 478
• Identity: 104/478 - (21%)
• Similarity: 187/478 - (39%)
• Gaps: 128/478 - (26%)

  Fly    52 DRLHAGLFTNYDSDVQPVFQ-GTPTNVSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQP 114
            ::|...|...|:..::||.. ..|..|..|:.:| .:::||:|..|.|:.||...|.|.:..|.|
 Frog    32 EKLFQKLLARYNQHIRPVENVSDPVMVHFEVAITQLVNVDEVNQILETNLWLRHIWNDYKLQWNP 96

  Fly   115 SQYDNITQITLKSSEVWTPQITLFNGDEGGLMAE--TQVTLSHDGHFRWMPPAVYTAYCELNMLN 177
            .:||.|..:.:.:.::|.|.|.|:|...|....|  ::..:.::|...|.|||::.:.|.:::..
 Frog    97 EEYDGIEFMRIPADKIWKPDIVLYNNAVGDFQVEGKSKALVKYNGLITWSPPAIFKSSCPMDITF 161

  Fly   178 WPHDKQSCKLKIGSWG-------LKVVLPENGTARGESLDHDDLVQSPEWEIVDSRA--HFVS-- 231
            :|.|.|:|.:|.|||.       |.::        |..:|..|..::.||||||:..  |.:.
 Frog   162 FPFDHQNCSMKFGSWSYDKAKIDLAII--------GSKVDMKDFWENSEWEIVDASGFKHDIKYN 218

  Fly   232 --QDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAF 294
              ::.|..:.|:...:|....||..:..|...:..|.:..|:||... |||:.:...:::.:..|
 Frog   219 CCEEIYTDITYSFYIRRLPMFYTINLIMPCLFLSFLTVLVFYLPSDC-GEKVTLCISVLLSLTVF 282

  Fly   295 LMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL---YLATGKHK----------RRLP 346
            |:...:.:|..|...|||..:...:::::::|.:|.|.||   |.....||          :|||
 Frog   283 LLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHKMPMWVKDVFLKRLP 347

  Fly   347 EALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHTEVPGAKANQF 411
            :.|                       ..:||.|....||.:.:.::|........:...|:..||
 Frog   348 KLL-----------------------MMKKTVEKKNRPYSKQNRKKSCEKSSELVDSESAEVEQF 389

  Fly   412 --------------------------------------------------------------DWA 414
                                                                          ||.
 Frog   390 EDESCYHCMRSKEQSSRVRRRQQRDSNGAVQECSSELTEVVDSIQFMAGNIRDHNERKEEEDDWK 454

  Fly   415 LLATAVDRISFVSFSLAFLILAI 437
            .:|..:||:    |...|::|.:
 Frog   455 YVAMVIDRV----FLWVFILLCV 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	104/476 (22%)
chrna6	XP_031759256.1	LIC	29..481	CDD:455710	104/478 (22%)
		LGIC_ECD	31..237	CDD:475126	58/212 (27%)