Protein Alignment nAChRbeta3 and chrna1

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: XP_002934647.1
• Gene: chrna1 / 100145177
• XenbaseID: XB-GENE-977139
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 438
• Identity: 112/438 - (25%)
• Similarity: 206/438 - (47%)
• Gaps: 71/438 - (16%)

  Fly    53 RLHAGLFTNYDSDVQPV--FQGTPTNVSLEM-VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQP 114
            ||...||.:|:..|:||  |:.... |:|.: ::..|::||:|..:||:..|..:|.|....|.|
 Frog    26 RLINDLFKSYNKVVRPVKAFKDKVV-VTLGLQLIQLINVDEVNQIVTTNVRLKQQWEDVHLKWNP 89

  Fly   115 SQYDNITQITLKSSEVWTPQITLFNGDEG--GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLN 177
            ..|..|.::.:.|.::|.|.|.|:|..:|  .::.||:|.|.:.|...|.|||::.:|||:.:..
 Frog    90 EDYGGIKKVRISSGDIWRPDIVLYNNADGDFAIVQETKVLLDYTGKIIWTPPAIFKSYCEMIVTY 154

  Fly   178 WPHDKQSCKLKIGSW----GLKVVLPENGTARGESLDHDDL---VQSPEWEIVDSRA--HFVSQD 233
            :|.|.|:|.:|:|:|    .|.|:.||:        |..||   ::|.||.:.|.|.  |:|
 Frog   155 FPFDLQNCSMKLGTWTYDGSLVVINPES--------DRPDLSNFMESGEWYMKDYRGWKHWV--- 208

  Fly   234 YYG------YME--YTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIV 290
            ||.      |::  |....||....:...:..|......|....|:||.. .||||.::..:::.
 Frog   209 YYDCCPETPYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTGLVFYLPTD-SGEKITLSVSVLLS 272

  Fly   291 IAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKRR-----LPEALR 350
            :..||:...:|:|..|:..||:..:...:::::..|.::.|:|:    ..|.|.     :|:.|:
 Frog   273 LVVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVITSIVITVIVI----NTHHRSPSTHIMPQWLK 333

  Fly   351 KLLHGHLGTWLLLSVFSTTGESQAEK---TKEMD---------------EHPYEEADEQESSPLG 397
            |:....:...:..|......:.|.:|   |:::|               :.|..:..:.:|:..|
 Frog   334 KIFIETIPRVMFFSTMKRPAQDQQKKKIFTEDIDISDISGKLGPAAVKYQSPILKNPDVKSAIEG 398

  Fly   398 INH------TEVPGAKANQFDWALLATAVDRISFVSFSLAFLI--LAI 437
            ..:      ::....||:: :|..:|..:|.:....|.:..:|  |||
 Frog   399 AKYIAETMKSDQESNKASE-EWKFVAMVLDHLLLAVFMIVCIIGTLAI 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	110/436 (25%)
		Neur_chan_LBD	52..247	CDD:280998	69/215 (32%)
		Neur_chan_memb	255..434	CDD:280999	38/207 (18%)
chrna1	XP_002934647.1	LIC	21..447	CDD:273305	112/438 (26%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	70/216 (32%)
		Cys-loop	148..162	CDD:349815	5/13 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100