DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spp and SPPL2A

DIOPT Version :9

Sequence 1:	NP_523444.1	Gene:	Spp / 33227	FlyBaseID:	FBgn0031260	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_005254779.1	Gene:	SPPL2A / 84888	HGNCID:	30227	Length:	538	Species:	Homo sapiens

Alignment Length:	390	Identity:	108/390 - (27%)
Similarity:	180/390 - (46%)	Gaps:	84/390 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PSTPEGMAVAYSSLV--VMAMLPIIFGSIRS--VKLHKLKKSTGEKADTMTKKD---------AM 85
            ||.|.   ..|:.:|  |:|:..:..|...|  |:|..||..|.|..:...||:         .:
Human   163 PSWPN---FDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVV 224

  Fly    86 YFPLIASAALFGLYLFFKIFQKVHINYLLTGYFFVLGVIALAHLLSPVINSLMPAAVPKVPFHIL 150
            .|.:|....:..||.|:|     .:.|::...|.:...::|.:.|:.:|:        |:|:...
Human   225 IFVVICCVMMVLLYFFYK-----WLVYVMIAIFCIASAMSLYNCLAALIH--------KIPYGQC 276

  Fly   151 FTKGEGKHKEDIVNYKFSTHDIVCLVISSAIGVWYLLKKH----WIANNLFGLAFAINGVEMLHL 211
            .....||:.|  |...|.:.  :|:.::.   ||.:.:..    ||..::.|:||.:|.::.|.|
Human   277 TIACRGKNME--VRLIFLSG--LCIAVAV---VWAVFRNEDRWAWILQDILGIAFCLNLIKTLKL 334

  Fly   212 NNFVTGVILLSGLFFYDIFWVF--------GTNVMVTVAKS------------FEA--------- 247
            .||.:.||||..|..||:|:||        |.::||.:|..            .||
Human   335 PNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKNDGNLVEATGQPSAPHE 399

  Fly   248 --PIKLVFPQDLIENGLNA--SNFAMLGLGDIVIPGIFIALLLRFDDSKKRKTRIYFYSTLIAYF 308
              |:.:..|:.:..:.::.  ...::||.|||::||:.||...|| |.:...:.||:.|:.:||.
Human   400 KLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRF-DVQTGSSYIYYVSSTVAYA 463

  Fly   309 LGLLATIFVMHVFKHAQPALLYLVPACMGTPLLVALIRGELKVLF---AYE--DH-----PEEKP 363
            :|::.|..|:.:.|..|||||||||..:.|..:||..|.|:|..:   :|:  ||     .||.|
Human   464 IGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENP 528

Fly 364 363
Human 529 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spp	NP_523444.1	Peptidase_A22B	71..358	CDD:282158	90/337 (27%)
SPPL2A	XP_005254779.1	PA_hSPPL_like	41..160	CDD:239044
SPPL2A	XP_005254779.1	Peptidase_A22B	210..514	CDD:282158	87/324 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810