Protein Alignment Spp and HM13

DIOPT Version :9

• Sequence 1: NP_523444.1
• Gene: Spp / 33227
• FlyBaseID: FBgn0031260
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_848696.1
• Gene: HM13 / 81502
• HGNCID: 16435
• Length: 426
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 226/419 - (53%)
• Similarity: 286/419 - (68%)
• Gaps: 58/419 - (13%)

  Fly    23 PKNESAPG-------EKKPSTPEGMAVAYSSLVVMAMLPIIFGSIRSVKLHKLKKSTGEKADTMT 80
            |.|.||..       .:.||||||:|:||.||::||:|||.||::|||:..: .|:..:..:|:|
Human     8 PHNGSAEAGGPTNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCAR-GKNASDMPETIT 71

  Fly    81 KKDAMYFPLIASAALFGLYLFFKIFQKVHINYLLTGYFFVLGVIALAHLLSPVINSLMPAAVPKV 145
            .:||..||:|||..|.|||||||||.:.:||.||:.||||||::||:|.:||.:|...||:.|..
Human    72 SRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPASFPNR 136

  Fly   146 PFHILFTKGEGKHKEDIVNYKFSTHDIVCLVISSAIGVWYLLKKHWIANNLFGLAFAINGVEMLH 210
            .:.:|||:|.|::||:|:||:|.|.|:|||.:||.:||||||:|||||||||||||::||||:||
Human   137 QYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLH 201

  Fly   211 LNNFVTGVILLSGLFFYDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLIENGLNASNFAMLGLGDI 275
            |||..||.|||.|||.||:||||||||||||||||||||||||||||:|.||.|:|||||||||:
Human   202 LNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDV 266

  Fly   276 VIPGIFIALLLRFDDSKKRKTRIYFYSTLIAYFLGLLATIFVMHVFKHAQPALLYLVPACMGTPL 340
            ||||||||||||||.|.|:.|..|||::..||..||..|||:||:|||||||||||||||:|.|:
Human   267 VIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPV 331

  Fly   341 LVALIRGELKVLFAY-------------------------------------------------- 355
            ||||.:||:..:|:|
Human   332 LVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYE 396

  Fly   356 EDHPEEKPEKKEKKEKDEGVSSSGSKKKE 384
            |.:|::.....|.||..|..:|.|.:|||
Human   397 ESNPKDPAAVTESKEGTEASASKGLEKKE 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spp	NP_523444.1	Peptidase_A22B	71..358	CDD:282158	190/336 (57%)
HM13	NP_848696.1	Peptidase_A22B	63..350	CDD:282158	189/286 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147364
Domainoid	1	1.000	406	1.000	Domainoid score	I707
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7749
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1563
Isobase	1	0.950	-	0	Normalized mean entropy	S2190
OMA	1	1.010	-	-		QHG52034
OrthoDB	1	1.010	-	-		D1087991at2759
OrthoFinder	1	1.000	-	-		FOG0004278
OrthoInspector	1	1.000	-	-		oto90106
orthoMCL	1	0.900	-	-		OOG6_102328
Panther	1	1.100	-	-	LDO	PTHR12174
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1942
SonicParanoid	1	1.000	-	-		X3016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750