DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spp and Hm13

DIOPT Version :9

Sequence 1:	NP_523444.1	Gene:	Spp / 33227	FlyBaseID:	FBgn0031260	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_006235330.1	Gene:	Hm13 / 311545	RGDID:	1308946	Length:	394	Species:	Rattus norvegicus

Alignment Length:	325	Identity:	214/325 - (65%)
Similarity:	267/325 - (82%)	Gaps:	1/325 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KKPSTPEGMAVAYSSLVVMAMLPIIFGSIRSVKLHKLKKSTGEKADTMTKKDAMYFPLIASAALF 96
            :.||||||:|:||.||::||:|||.||::|||:..: .||:.:..:|:|.:||..||:|||..|.
  Rat    24 RPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCAR-GKSSSDMPETITSRDAARFPIIASCTLL 87

  Fly    97 GLYLFFKIFQKVHINYLLTGYFFVLGVIALAHLLSPVINSLMPAAVPKVPFHILFTKGEGKHKED 161
            |||||||:|.:.:||.||:.||||||::||:|.:||.:|...||..|...:.:|||:|.|::||:
  Rat    88 GLYLFFKLFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLLFTQGSGENKEE 152

  Fly   162 IVNYKFSTHDIVCLVISSAIGVWYLLKKHWIANNLFGLAFAINGVEMLHLNNFVTGVILLSGLFF 226
            |:||:|.|.|:|||.:||.:||||||:|||||||||||||::||||:|||||..||.|||.|||.
  Rat   153 IINYEFDTKDLVCLGLSSVVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFI 217

  Fly   227 YDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLIENGLNASNFAMLGLGDIVIPGIFIALLLRFDDS 291
            |||||||||||||||||||||||||||||||:|.||.|.||||||||||||||||||||||||.|
  Rat   218 YDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALLLRFDIS 282

  Fly   292 KKRKTRIYFYSTLIAYFLGLLATIFVMHVFKHAQPALLYLVPACMGTPLLVALIRGELKVLFAYE 356
            .|:.|..|||::..||..||..|||:||:|||||||||||||||:|.|:||||::||:..:|:||
  Rat   283 LKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALVKGEVAEMFSYE 347

Fly 357 356
Rat 348 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spp	NP_523444.1	Peptidase_A22B	71..358	CDD:282158	192/286 (67%)
Hm13	XP_006235330.1	Peptidase_A22B	62..350	CDD:282158	192/286 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341016
Domainoid	1	1.000	407	1.000	Domainoid score	I688
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7749
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1513
OMA	1	1.010	-	-		QHG52034
OrthoDB	1	1.010	-	-		D1087991at2759
OrthoFinder	1	1.000	-	-		FOG0004278
OrthoInspector	1	1.000	-	-		oto97224
orthoMCL	1	0.900	-	-		OOG6_102328
Panther	1	1.100	-	-	LDO	PTHR12174
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3016
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810