DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spp and Sppl2a

DIOPT Version :9

Sequence 1:	NP_523444.1	Gene:	Spp / 33227	FlyBaseID:	FBgn0031260	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_006234982.1	Gene:	Sppl2a / 311401	RGDID:	1563001	Length:	541	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	110/403 - (27%)
Similarity:	178/403 - (44%)	Gaps:	98/403 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PSTPEGMAVAYSSLV--VMAMLPIIFGSIRS--VKLHKLKK-STGEKADTMTKKD---------A 84
            ||.|.   ..|:.:|  |:|:..:..|...|  ::|..:|. ...|..:...||:         .
  Rat   166 PSWPN---FDYTLVVIFVIAVFTVALGGYWSGLIELESMKAVEDAEDREARKKKEDYLTFSPLTV 227

  Fly    85 MYFPLIASAALFGLYLFFKIFQKVHINYLLTGYFFVLGVIALAHLLSPVINSLMPAAVPKVPFHI 149
            :.|.:|....:..||.|:|     .:.|::...|.:....:|.:.|:.:|:. ||.
  Rat   228 VLFVVICCVMIVLLYFFYK-----WLVYVMIAIFCIASATSLYNCLAALIHR-MPC--------- 277

  Fly   150 LFTKGE------GKHKEDIVNYKFSTHDIVCLVISSAIGVWYLLKKH----WIANNLFGLAFAIN 204
                |:      ||      |.|.|...:..|.||.|: ||.:.:..    ||..::.|:||.:|
  Rat   278 ----GQCTILCCGK------NIKVSLIFLSGLCISVAV-VWAVFRNEDRWAWILQDILGIAFCLN 331

  Fly   205 GVEMLHLNNFVTGVILLSGLFFYDIFWVF--------GTNVMVTVAKS-FE-------------- 246
            .::.:.|.||::.||||..|..||:|:||        |.::||.:|.. ||
  Rat   332 LIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKNDGNFVEATA 396

  Fly   247 --------APIKLVFPQ--DLIENGLNASNFAMLGLGDIVIPGIFIALLLRFDDSKKRKTRIYFY 301
                    .|:.:..|:  |.....:.:...::||.|||::||:.||...|||  .:..:.||:.
  Rat   397 LHSAPHEKLPVVIRVPKLMDYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFD--VQTGSSIYYI 459

  Fly   302 STLIAYFLGLLATIFVMHVFKHAQPALLYLVPACMGTPLLVALIRGELKVLFA--------YEDH 358
            |:.|||.:|::.|..|:.|.|..|||||||||..:.|..:||..|.|:|..:.        |.|:
  Rat   460 SSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITASIVAWSRKEMKKFWKGSSYQVMDYLDY 524

  Fly   359 P--EEKPEKKEKK 369
            .  ||.|...:::
  Rat   525 STNEENPAATDEQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spp	NP_523444.1	Peptidase_A22B	71..358	CDD:282158	95/346 (27%)
Sppl2a	XP_006234982.1	Peptidases_S8_S53	44..163	CDD:299169
Sppl2a	XP_006234982.1	Peptidase_A22B	214..517	CDD:282158	93/330 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810