Protein Alignment Spp and SPPL3

DIOPT Version :9

• Sequence 1: NP_523444.1
• Gene: Spp / 33227
• FlyBaseID: FBgn0031260
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_620584.2
• Gene: SPPL3 / 121665
• HGNCID: 30424
• Length: 384
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 114/399 - (28%)
• Similarity: 174/399 - (43%)
• Gaps: 103/399 - (25%)

  Fly    43 AYS-------SLVVMAMLPIIFGSIRSVKL-----HKLK-----------KSTGEKADTMTKKDA 84
            |||       |..::::|.|::||.||:.:     .|.|           .||.....|:....|
Human     9 AYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSNSSSGSFNGNSTNNSIQTIDSTQA 73

  Fly    85 MYFPLIASAALFGLYLFFKIFQKVHINYLLTGYFFVLGVIALAHLLSPVINSLMPAAVP--KVPF 147
            ::.|:.||.:|..::.||...|.|     .|....||..||.|.||.|:...|.....|  |:.|
Human    74 LFLPIGASVSLLVMFFFFDSVQVV-----FTICTAVLATIAFAFLLLPMCQYLTRPCSPQNKISF 133

  Fly   148 HIL--FTKGEGKHKEDIVNYKFSTHDIVCLVISSAIGVWYLLKKHWIANNLFGLAFAINGVEMLH 210
            ...  ||..|      ::::..|    |.||:     :| :|..||:..:...:...:..:..:.
Human   134 GCCGRFTAAE------LLSFSLS----VMLVL-----IW-VLTGHWLLMDALAMGLCVAMIAFVR 182

  Fly   211 LNNFVTGVILLSGLFFYDIFWV------FGTNVMVTVAKS------------------------- 244
            |.:.....:|||||..||:|||      |.:||||.||..
Human   183 LPSLKVSCLLLSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPNVGRDVPR 247

  Fly   245 FEAPIKLVFPQDLIENGLNASNFAMLGLGDIVIPGIFIALLLRFDDSKK---------------- 293
            ...|.|||||..      ..|:|:|||:||||:||:.:..:||:|:.||
Human   248 LSLPGKLVFPSS------TGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANIS 306

  Fly   294 -RKTRI-YFYSTLIAYFLGLLATIFVMHVFKHAQPALLYLVPACMGTPLLVALIRGELKVLFAYE 356
             |..:: ||:.|||.||:|||.......:.:.||||||||||..:...|.:|.::|:|:.:::..
Human   307 GRMQKVSYFHCTLIGYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEP 371

  Fly   357 DHPEEKPEK 365
            .|.:....:
Human   372 FHSKSSSSR 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spp	NP_523444.1	Peptidase_A22B	71..358	CDD:282158	101/339 (30%)
SPPL3	NP_620584.2	Peptidase_A22B	61..374	CDD:282158	100/339 (29%)
		PAL	341..343		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52034
OrthoDB	1	1.010	-	-		D1087991at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1942
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860