DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ush and ZFPM2

DIOPT Version :9

Sequence 1:	NP_001259829.1	Gene:	ush / 33225	FlyBaseID:	FBgn0003963	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_036214.2	Gene:	ZFPM2 / 23414	HGNCID:	16700	Length:	1151	Species:	Homo sapiens

Alignment Length:	1352	Identity:	262/1352 - (19%)
Similarity:	425/1352 - (31%)	Gaps:	454/1352 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EQKQQQMEDQLEDQLNDSRD--------------------------PQNNN--------NNIDD- 63
            :.|.:|::..|||.:.|..:                          |:|.:        |..||
Human     6 QSKPRQIKRPLEDAIEDEEEECPSEETDIISKGDFPLEESFSTEFGPENLSCEEVEYFCNKGDDE 70

  Fly    64 ------DADEDAEFEEPEKANPQQD--QDLGETEMEQEHDLQQEDLQQELPA------------- 107
                  ::|.|.:.|:|.:...:.|  ...||.|:.|:...::...:|:||.
Human    71 GIQETAESDGDTQSEKPGQPGVETDDWDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDL 135

  Fly   108 --NSPSTPPRSPSSPQLIPK-LEQPATPPSEPEASPCPSPSP-----CPTPK--YPKVRLNALLA 162
              ||..|..:.|......|| |........|...:.|...|.     |.|.|  .....|.|.:.
Human   136 NNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVV 200

  Fly   163 SDPALKPDAKELTLPD----SRLLAPPPLVKPDTQAQPEVAEPLLKPARFMCLPCGIAFSSPSTL 223
            ...:....|.::||.:    :|||....|:.........:...::....|.|..|||.:.|...|
Human   201 DFDSRLQAASQMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNL 265

  Fly   224 EAHQAYYCSHRIKD---TDEAGSDK-----------------SGAGGSGATAGDAAGLTGGSTEP 268
            :||..||||.|.::   ..|...|.                 |.|..........:|:......|
Human   266 QAHLMYYCSGRQREAAPVSEENEDSAHQISSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLP 330

  Fly   269 PAKMARTGKQYGCTQCSYSADKKVSLNRHMRMHQTSPAAPTLAGLPSLLQNGIAPPGVTPNPMED 333
            |      |....||.|||:||..::.::|:..|.|..|.
Human   331 P------GASLKCTVCSYTADSVINFHQHLFSHLTQAAF-------------------------- 363

  Fly   334 SSSQQTDRYCSHCDIRFNNIKTYRAHKQHYCSSRRPEGQLTPKPDASPGAGSGPGSAGGSIGVSA 398
                    .|:||...|...:....|::.:.    |.|:|..:.|..    ..|.:...|:..:.
Human   364 --------RCNHCHFGFQTQRELLQHQELHV----PSGKLPRESDME----HSPSATEDSLQPAT 412

  Fly   399 QAATPGKLSPQARNKTPTPAMVAVAAAAAAAAASLQATPHSHPPFLALPTHPIIIVPCSLIRAAS 463
            ...|..:| ||::.        |:....|::...|.........||
Human   413 DLLTRSEL-PQSQK--------AMQTKDASSDTELDKCEKKTQLFL------------------- 449

  Fly   464 FIPGPLPTPNSGIVNPETTCFTVDNGTIKPLATALVGATLEPERPSAPSSAAEATEAKSSPPEPK 528
                   |.....:.|.|...:.....||.          ||..|...||..:.....|.|..|
Human   450 -------TNQRPEIQPTTNKQSFSYTKIKS----------EPSSPRLASSPVQPNIGPSFPVGP- 496

  Fly   529 RKEAGLTRESAPLDLSL--RRSPITLNSLSLRQRQLRNALLDVEEVLLAGVGTGKENVETPRGGG 591
                .|::.|.|.|:::  :.|.|......|..|:||:.......|:.:.:        .|:|..
Human   497 ----FLSQFSFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPL--------MPKGAT 549

  Fly   592 ----------------------SVTPEQIVCAPSLPSSPSMSPSPKRRAISPRSSGAGSASSMSP 634
                                  |...:|:..:|..||.....|    .|:|| ::|..|.:.::|
Human   550 CFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMP----EALSP-NTGQTSINLLNP 609

  Fly   635 PGLNVAVPHLLDMRSMLPADFGLSESLLAKTNPELALKLAAAAAAAAVAGSSGAA---AFPPASL 696
                  ..|..|                 ..||.|......::....:.|.:|..   .|...:.
Human   610 ------AAHSAD-----------------PENPLLQTSCINSSTVLDLIGPNGKGHDKDFSTQTK 651

  Fly   697 PAQTSSGNPGS-GGSAGGAQQPQIYVKKGVS-----KCMECNIVFCKYENYLAHKQHYCSARS-- 753
            ...|||.|... .|.....:.|.:.:..|.|     .|..|||.|.::|.|:.|||:||:.|.
Human   652 KLSTSSNNDDKINGKPVDVKNPSVPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDP 716

  Fly   754 --QEGASE------------------------------------VDVKSAVSPSIA------GAG 774
              :..||.                                    :||.:..:|..:      |.|
Human   717 PLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLNNPCTSTQEPTEGLG 781

  Fly   775 -----------GLGAGAAEAA----------------SSV-------------------ETTPVA 793
                       |:.:...|.:                |||                   |.|..:
Human   782 ECYHPRCDIFPGIVSKHLETSLTINKCVPVSKCDTTHSSVSCLEMDVPIDLSKKCLSQSERTTTS 846

  Fly   794 YQQLI----CAACGIKYTSLDNLRAHQNYYCPKGGAVAAPAATPTDPGQLGMPKEKCGKCKTLHE 854
            .::|:    |..|.|.:..::|..||:..:||      ..|....|.|||.      ||.
Human   847 PKRLLDYHECTVCKISFNKVENYLAHKQNFCP------VTAHQRNDLGQLD------GKV----- 894

  Fly   855 IGLPCPPPVANPLAAPTVNPQPATNSLNKCPVCGVV---SPTAALAKKHMEMHGTVKAYRCSICQ 916
              .|.|....|   :|.|:.:   .|:.||...|.:   ||...|...|:.
Human   895 --FPNPESERN---SPDVSYE---RSIIKCEKNGNLKQPSPNGNLFSSHLA-------------- 937

  Fly   917 YKGNTLRGMRTHIRTHFDKKTSDVNEELYM-TCIFEEDASALSQELVTPTGASTTTGHDSMDHPS 980
                ||:|::..........|.:.|..|:: .|::             |.......|.|.:   |
Human   938 ----TLQGLKVFSEAAQLIATKEENRHLFLPQCLY-------------PGAIKKAKGADQL---S 982

  Fly   981 QMFNCDYCNYVSTYKGNVLRHMKLMHPHVAINSPSISPDTRDQDVTSN----------PTTNQHS 1035
            ..:.....:|:|   |:::.|...:..  :.|:.:.||..:   .:||          |...::.
Human   983 PYYGIKPSDYIS---GSLVIHNTDIEQ--SRNAENESPKGQ---ASSNGCAALKKDSLPLLPKNR 1039

  Fly  1036 NSDVSNG-----EAPSFHIKSEPLDPPPTVNLVHENNN-SPIATPHIKAEPIEVGADAAPGGLVP 1094
            ...:.||     |.|:.:.:.|.:...|.    ||::: ||   ..|...|:....:.:||  :|
Human  1040 GMVIVNGGLKQDERPAANPQQENISQNPQ----HEDDHKSP---SWISENPLAANENVSPG--IP 1095

  Fly  1095 PMTSPLGNSSSVAAA--AAAAAEVMKKYCSTCDISFNYVKTYLAHKQFYCKN 1144
            .....|   ||:|..  .::.|....|||..|||.||.:..::.||:|||.:
Human  1096 SAEEQL---SSIAKGVNGSSQAPTSGKYCRLCDIQFNNLSNFITHKKFYCSS 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ush	NP_001259829.1	C2H2 Zn finger	884..904	CDD:275370	6/22 (27%)
		C2H2 Zn finger	912..932	CDD:275370	3/19 (16%)
		zf-H2C2_5	983..1007	CDD:290620	4/23 (17%)
ZFPM2	NP_036214.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		16/95 (17%)
		zf-C2H2_8	298..388	CDD:292531	22/133 (17%)
		C2H2 Zn finger	301..320	CDD:275368	2/18 (11%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..487		24/146 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..683		10/46 (22%)
		Nuclear localization signal. /evidence=ECO:0000250	736..740		0/3 (0%)
		Interaction with CTBP2. /evidence=ECO:0000305	829..835		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1051..1095		12/52 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4347
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003584
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12958
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7185
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	6.040