DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ush and Zfpm2

DIOPT Version :9

Sequence 1:	NP_001259829.1	Gene:	ush / 33225	FlyBaseID:	FBgn0003963	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_035896.1	Gene:	Zfpm2 / 22762	MGIID:	1334444	Length:	1151	Species:	Mus musculus

Alignment Length:	1420	Identity:	259/1420 - (18%)
Similarity:	406/1420 - (28%)	Gaps:	590/1420 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EQKQQQMEDQLEDQLNDSR--------------------------DPQN-------------NNN 59
            :.|.:|::..|||.::|..                          :|:|             ::.
Mouse     6 QSKPRQIKRPLEDAIDDEEEECPVEEAEVISKGDFPLEGSFPAGFEPENLSCEDVEFFCNKGDDE 70

  Fly    60 NIDDDADEDAEFEEPEKANPQQDQD----LGETEMEQEHDLQQEDLQQELPA------------- 107
            .|.:.|:.|.:....:...|..:.|    .||.|:.|....::...:|:||.
Mouse    71 GIQEPAESDGDSHSDKPGQPGVETDDWDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDL 135

  Fly   108 --NSPSTPPRSPSSPQLIPK-LEQPATPPSEPEASPCPSPSP-----CPTPK--YPKVRLNALLA 162
              ||..|..:.|......|| |........|...:.|...|.     |.|.|  .....|.|.:.
Mouse   136 NNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDSKNNCIVYSKGGQLWCTTTKAISEGEELVAFVV 200

  Fly   163 SDPALKPDAKELTLPD----SRLLAPPPLVKPDTQAQPEVAEPLLKPARFMCLPCGIAFSSPSTL 223
            ...:....|..:||.:    :|||....|:.........:...::....|.|..|||.:.|...|
Mouse   201 DFDSRLQAASHMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNL 265

  Fly   224 EAHQAYYCSHRIKD---TDEAGSDKSGAGGS-------GATAGDAAGL-------TGGSTE---P 268
            :||..||||.|.::   ..|...|.|....|       ..:..:|..|       :|...|   |
Mouse   266 QAHLMYYCSGRQREAAPVSEENEDNSHQVSSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLP 330

  Fly   269 PAKMARTGKQYGCTQCSYSADKKVSLNRHMRMHQTSPAAPTLAGLPSLLQNGIAPPGVTPNPMED 333
            |      |....||.|||:||..::.::|:..|.|..|.
Mouse   331 P------GASLKCTVCSYTADSVINFHQHLFSHLTQAAF-------------------------- 363

  Fly   334 SSSQQTDRYCSHCDIRFNNIKTYRAHKQHYCSSRRPEGQLTPKPDA--SPGAGSGPGSAGGSIGV 396
                    .|:||...|...:....|::.:.    |.|:|..:.|.  ||
Mouse   364 --------RCNHCHFGFQTQRELLQHQELHV----PSGKLPRESDMEHSP--------------- 401

  Fly   397 SAQAATPGKLSPQARNKTPTPAMVAVAAAAAAAAASLQATPHSHPPFLALPTHPIIIVPCSLIRA 461
               :.|...|.|               |....|.:.|..:..:
Mouse   402 ---SGTEDSLQP---------------ATDLLARSDLSQSQKA---------------------- 426

  Fly   462 ASFIPGPLPTPNSGIVNPETTCFTVDNGTIKPLATALVGATLEPE-RPSAPSSAAEATEAKSSPP 525
                   :||.::........|         ...|.|......|| :|:|.......|:.||.|.
Mouse   427 -------MPTKDASSDTELDKC---------EKKTQLFLTNQRPEIQPAANKQNFSYTKIKSEPS 475

  Fly   526 EPKRKEAGLTRESAPLDLSLRRSPITLNSLSLRQRQLRNALLDVEEVLLAGVGTGKENVETPRGG 590
            .|:                |..||:..|                       :|
Mouse   476 SPR----------------LASSPVQPN-----------------------IG------------ 489

  Fly   591 GSVTPEQIVCAPSLPSSPSMSPSPKRRAISPRSSGAGSASSMSPPGLNVAVPHLLDMRSMLPADF 655
                       ||.|..|.:|                          ..|.|..:   :|:|.
Mouse   490 -----------PSFPVGPFLS--------------------------QFAFPQDI---TMVPQ-- 512

  Fly   656 GLSESLLAKTNPELALKLAAAAAAAAVAGSSGAAAFPPASLPAQTSSGNPGSGGSAGGAQQPQIY 720
              :..:|||.:..:..:|           ..|::::||.                        ||
Mouse   513 --ASEILAKMSELVHRRL-----------RHGSSSYPPV------------------------IY 540

  Fly   721 ---VKKGVSKCMECNIVFCKYENYLAHKQHYCSARSQEGASEVDVKS-------AVSPS------ 769
               :.||.: |.||||.|...:|||.||:||||:|.|:.|...:..|       ||||:
Mouse   541 SPLMPKGAT-CFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMPEAVSPNTGQTSI 604

  Fly   770 -----------------------------IAGAGGLGAGAAEAASSVETTPVAY----------- 794
                                         :.|..|.| ...:.::.|:..|.:.
Mouse   605 NLLNPAAHSSDPENPLLQTSCINSSTVLDLIGPNGKG-HEKDFSTQVKKLPTSNSSDDKINGKPV 668

  Fly   795 ----------------QQLICAACGIKYTSLDNLRAHQNYYCPKGGAVAAPAATPTDPGQLGMPK 843
                            .:..|.||.|.::..:....|:.|||          ||..||     |.
Mouse   669 DVKNPSGPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYC----------ATRHDP-----PL 718

  Fly   844 EKCG--------------KCKTLHEIGLP----CPP-------PVANPLAAPTVNPQPATNSLNK 883
            ::..              |.:.::|:.||    .||       .||| |:.|..:.|..|..|.:
Mouse   719 KRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVAN-LSNPCSSTQEPTEGLGE 782

  Fly   884 C--PVC----GVVSPTAALAKKHME----------------MHGTVKA----------------- 909
            |  |.|    |:||       ||:|                .|..|..
Mouse   783 CYHPRCDIFPGIVS-------KHLETSLAMNKCVPVPKCDTTHSNVSCLEMDVPIDLSKKCLSQS 840

  Fly   910 -------------YRCSICQYKGNTLRGMRTH------IRTHFDKKTSDVNEELYMTCIFEEDAS 955
                         :.|::|:...|.:.....|      :..|.......::.:::.....|..:.
Mouse   841 ERTTASPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERSSP 905

  Fly   956 ALSQE-------------LVTPTG------ASTTTGHDSMDHPSQMF------------NCDYCN 989
            .:|.|             ..:|.|      .:|..|.......:|:.            .|.|..
Mouse   906 EVSFERNMIKCEKNGNPKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENKHLFLPQCLYPG 970

  Fly   990 YVSTYKGNVLRHMKLMHPHVAIN-----SPSISPDTRDQDVTSNPTTNQHSNSDVSNGEAPSFHI 1049
            .:...||     ...:.|:..|.     :.|:.....|.:.::| |.|:......|:........
Mouse   971 AIKKTKG-----ADQLSPYYGIKPSDYIASSLVIHNTDVEQSTN-TENESPKGQASSNGCAVPKK 1029

  Fly  1050 KSEPL----------------DPPPTVNLVHEN--NNSPIATPH-----IKAEPIEVGADAAPGG 1091
            .|.||                |..||.|...||  .|:.....|     |...|:....:.:||
Mouse  1030 DSLPLLPKNRGMVIVNGGLKQDERPTANPQQENISQNTQHEDGHKSPSWISENPLAANENVSPG- 1093

  Fly  1092 LVPPMTSPLGNSSSVAAAAAAAAEVMK--KYCSTCDISFNYVKTYLAHKQFYCKN 1144
             :|.....|   ||:|.....|::...  |||..|||.||.:..::.||:|||.:
Mouse  1094 -IPCAEEQL---SSIAKGVNGASQAPSSGKYCRLCDIQFNNLSNFITHKKFYCSS 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ush	NP_001259829.1	C2H2 Zn finger	884..904	CDD:275370	9/41 (22%)
		C2H2 Zn finger	912..932	CDD:275370	4/25 (16%)
		zf-H2C2_5	983..1007	CDD:290620	4/35 (11%)
Zfpm2	NP_035896.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		6/46 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..101		5/35 (14%)
		zf-C2H2_8	298..388	CDD:292531	23/133 (17%)
		C2H2 Zn finger	301..320	CDD:275368	2/18 (11%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..486		28/183 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..684		4/47 (9%)
		Nuclear localization signal	736..740		1/3 (33%)
		Interaction with CTBP2. /evidence=ECO:0000305	829..835		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1035		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1049..1093		10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4749
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003584
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12958
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7185
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	6.040