DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ush and ZFPM1

DIOPT Version :9

Sequence 1:	NP_001259829.1	Gene:	ush / 33225	FlyBaseID:	FBgn0003963	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	XP_011521214.1	Gene:	ZFPM1 / 161882	HGNCID:	19762	Length:	1052	Species:	Homo sapiens

Alignment Length:	1261	Identity:	280/1261 - (22%)
Similarity:	386/1261 - (30%)	Gaps:	480/1261 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 QQDQDLGETEMEQEHDLQQEDLQQELPANSPS--TPPRSPSSPQLI--------PKLEQPATPPS 134
            ::.|.:|.:.|||:....:.........|||.  .||.||..|:.:        |..|:|.:|.|
Human    69 EEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWS 133

  Fly   135 EPE------------------------------------ASPC---PSPS--------PCPTPKY 152
            .|:                                    :||.   |||:        .|.....
Human   134 GPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTL 198

  Fly   153 PKVRLNALLASDPALKPDAK--ELTLPD------SRLLAPPPLVKPDTQAQPEVAEPL------- 202
            |:....|...::...|.||.  .:|.|.      |.||...|...|....:.|.|||.
Human   199 PQALTEAEANTEIHRKDDALWCRVTKPVPAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHD 263

  Fly   203 --LKPAR----------------FMCLPCGIAFSSPSTLEAHQAYYCSHRIKDTDEAGSDKSGAG 249
              |.|.:                |.|..|||.:.|...|:||..|||:.|           .|.|
Human   264 LQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASR-----------QGTG 317

  Fly   250 GSGATAGDAAGLTGGSTEPPAKMARTGKQYGCTQCSYSADKKVSLNRHMRMHQTSPAAPTLAGLP 314
            ...|.|.|         |.|.:.....:.....||..|.....||..|||.|........|..|.
Human   318 SPAAAATD---------EKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLS 373

  Fly   315 SLLQNGIAPPGVTPNPMEDSSSQQTDR---YCSHC-------DIRFNNIKTYRAHKQHYCSSRRP 369
            :.         .|....|......||.   .|..|       ||.::::.|     .|.......
Human   374 AF---------TTKANCERHLKVHTDTLSGVCHSCGFISTTRDILYSHLVT-----NHMVCQPGS 424

  Fly   370 EGQLTPKPDASPGAGSGPGSAGGSIGVSAQAATPGKLSPQARNKTPTPAMVAVAAAAAAAAASLQ 434
            :|::     .|||||              ..||  ||.|.                      ||.
Human   425 KGEI-----YSPGAG--------------HPAT--KLPPD----------------------SLG 446

  Fly   435 ATPHSHPPFLALPTHPIIIVPCSLIRAASFIPGPL--------PTPNSGIVNPETTCFTVDNGTI 491
            :....|                      :.:.|||        |||:.|:........|......
Human   447 SFQQQH----------------------TALQGPLASADLGLAPTPSPGLDRKALAEATNGEARA 489

  Fly   492 KPLATALVGATLEPERPSAPSS-AAEATEAKSSPPEPKRKEAGLTRESAPLDLSLRRSPITLNSL 555
            :|||..  |.:.||  |:||.| ..||.|      ||         |:||:
Human   490 EPLAQN--GGSSEP--PAAPRSIKVEAVE------EP---------EAAPI-------------- 521

  Fly   556 SLRQRQLRNALLDVEEVLLAGVGTGKENVETPRGGGSVTPEQIVCAPSLPSSPSMSPSPKRRAIS 620
                                 :|.|:..                     |.:||.:|||:    |
Human   522 ---------------------LGPGEPG---------------------PQAPSRTPSPR----S 540

  Fly   621 PRSSGAGSASSMSPPGLNVAVPHLLDMRSMLPADFGLSESLLAKTNPELALKLAAAAAAAAVAGS 685
            |..:...:..|...||           .|.:|.:.||:.:|..   |:...
Human   541 PAPARVKAELSSPTPG-----------SSPVPGELGLAGALFL---PQYVF-------------- 577

  Fly   686 SGAAAFPPAS-LPAQTSS-----GNPGSGGSAGGAQQ---PQIYVKKGVSKCMECNIVFCKYENY 741
             |..|.|||| :.|:.|.     ...|:|..|||||.   |.  ..||.: |.||.|.|....||
Human   578 -GPDAAPPASEILAKMSELVHSRLQQGAGAGAGGAQTGLFPG--APKGAT-CFECEITFSNVNNY 638

  Fly   742 LAHKQHYCSARSQ-----------------------------------EGASEVDVKSAVSPSIA 771
            ..||:.|||.|..                                   .||.|.....|.:|. .
Human   639 YVHKRLYCSGRRAPEDAPAARRPKAPPGPARAPPGQPAEPDAPRSSPGPGAREEGAGGAATPE-D 702

  Fly   772 GAGGLGA-GAAEAASSVETTPVAYQQLICAACGIKYTSLDNLRAHQNYYC-------------PK 822
            ||||.|: |:....|||:.......:.:|.||.|:::..:....|:.|||             |.
Human   703 GAGGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAPP 767

  Fly   823 G--GAVAAPAATPTDPGQLGMPKEKCGKCKTLHEIGLPCPPPV----------------ANPLAA 869
            |  |..|.||.:|..|    :...:..|...||..|.|.|||.                :.|..|
Human   768 GPPGPAAPPAPSPAAP----VRTRRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPGLA 828

  Fly   870 PTVNPQPATN---SLNK---CPVCGVVSPTAALAKKHMEMHGTVKAYRCSICQYKGNTLRGMRTH 928
            |..:|.||.:   .|:|   .|:.|  :|..|||..|          .|:.|:...::|.....|
Human   829 PARSPGPAADGPIDLSKKPRRPLPG--APAPALADYH----------ECTACRVSFHSLEAYLAH 881

  Fly   929 IRTHFDKKTSDVNEELYMTCIFEEDASALSQELVTPTGASTTTGHDSMDHPSQMFNCDYCNYVST 993
                  ||.|         |.......||.    .|..|                 |.||.....
Human   882 ------KKYS---------CPAAPPPGALG----LPAAA-----------------CPYCPPNGP 910

  Fly   994 YKGNVLRHMKLMHPHVAINSPSISPDTR-----DQDVTSNPTTNQHSNSDVSNGEAPSFHIKSEP 1053
            .:|::|.|.:|.| .:.:.:|...|...     |:..:..|..   :.|.......|...:..||
Human   911 VRGDLLEHFRLAH-GLLLGAPLAGPGVEARTPADRGPSPAPAP---AASPQPGSRGPRDGLGPEP 971

  Fly  1054 LDPPPTVNLVHENNNSPIATPHIKAEPIEVGADAAPGGLVPPMTSPLGNSSSVAAAAAAAAEVMK 1118
            .:|||      ....||.|.|           :|.|....||..|..|..:......|.......
Human   972 QEPPP------GPPPSPAAAP-----------EAVPPPPAPPSYSDKGVQTPSKGTPAPLPNGNH 1019

  Fly  1119 KYCSTCDISFNYVKTYLAHKQFYCKN 1144
            :||..|:|.|:.:.|::|||::||.:
Human  1020 RYCRLCNIKFSSLSTFIAHKKYYCSS 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ush	NP_001259829.1	C2H2 Zn finger	884..904	CDD:275370	7/19 (37%)
		C2H2 Zn finger	912..932	CDD:275370	4/19 (21%)
		zf-H2C2_5	983..1007	CDD:290620	7/23 (30%)
ZFPM1	XP_011521214.1	C2H2 Zn finger	289..315	CDD:275368	12/36 (33%)
		C2H2 Zn finger	341..360	CDD:275368	8/18 (44%)
		zf-H2C2_2	352..377	CDD:290200	8/33 (24%)
		C2H2 Zn finger	368..388	CDD:275368	4/28 (14%)
		C2H2 Zn finger	396..413	CDD:275368	4/16 (25%)
		Suf	<502..595	CDD:283497	39/196 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143582
Domainoid	1	1.000	85	1.000	Domainoid score	I8189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4347
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003584
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.950