DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and CRZ1

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_014371.1	Gene:	CRZ1 / 855704	SGDID:	S000004972	Length:	678	Species:	Saccharomyces cerevisiae

Alignment Length:	415	Identity:	94/415 - (22%)
Similarity:	148/415 - (35%)	Gaps:	130/415 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NENLLKAKLKLVAQKSQKNGGIITPNPSDTEDEAPEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQ 96
            :.|||.|...  :..:..|.|||  |.:||::..  ||:...|....| .|.:|.|.........
Yeast   267 DNNLLSASNN--SDFNNSNNGII--NTADTQNST--IAINKSKVGTNQ-KMLLTIPTSSTPSPST 324

  Fly    97 KAERVSVIMRV------------NSSGAVSSSSQDENSSSSTSCCSSSSN---------TNTSTS 140
            .|..|:.|:.:            ...|.:....:|..|.|:|    :::|         .|.:.|
Yeast   325 HAAPVTPIISIQEFNEGHFPVKNEDDGTLQLKVRDNESYSAT----NNNNLLRPDDNDYNNEALS 385

  Fly   141 SVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIKEEEIK--- 202
            .:..:.||...    .|.||.|.:|:|:::.:.....:..:..::.::|...|:.|.....|
Yeast   386 DIDRSFEDIIN----GRKLKLKKSRRRSSQTSNNSFTSRRSSRSRSISPDEKAKSISANREKLLE 446

  Fly   203 ----------------------------------------PILT--PIYVSPVASSASQL----- 220
                                                    .:||  |...|.:.:..::|
Yeast   447 MADLLPSSENDNNRERYDNDSKTSYNTINSSNFNEDNNNNNLLTSKPKIESGIVNIKNELDDTSK 511

  Fly   221 ---ILLSTVAAQQ------------------SPTPVPKTPTMSEEKLTTRITAAQAAATRSRIYE 264
               |||...:..|                  ....|.|...:  |||.        :.|.:|...
Yeast   512 DLGILLDIDSLGQFEQKVGFKNDDNHENNDNGTFSVKKNDNL--EKLD--------SVTNNRKNP 566

  Fly   265 CSF--PDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCS- 326
            .:|  ..|||.:.:..:||:|.|.||.||||||  ..|.|.|:|..:..||:..|||:|::.|.
Yeast   567 ANFACDVCGKKFTRPYNLKSHLRTHTNERPFIC--SICGKAFARQHDRKRHEDLHTGKKRYVCGG 629

  Fly   327 --------VCQKKFMRSDHLSKHVK 343
                    .|.|||.|||.|.:|.|
Yeast   630 KLKDGKPWGCGKKFARSDALGRHFK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	8/25 (32%)
		C2H2 Zn finger	265..287	CDD:275368	8/23 (35%)
		COG5048	<270..362	CDD:227381	36/83 (43%)
		zf-H2C2_2	279..306	CDD:290200	15/26 (58%)
		C2H2 Zn finger	295..317	CDD:275368	7/21 (33%)
		zf-H2C2_2	309..332	CDD:290200	9/31 (29%)
		zf-C2H2	323..345	CDD:278523	11/30 (37%)
		C2H2 Zn finger	325..345	CDD:275368	11/28 (39%)
CRZ1	NP_014371.1	COG5048	139..617	CDD:227381	79/376 (21%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	599..619	CDD:275368	7/21 (33%)
		C2H2 Zn finger	627..655	CDD:275368	11/28 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960