DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and MSN2

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_013751.1	Gene:	MSN2 / 855053	SGDID:	S000004640	Length:	704	Species:	Saccharomyces cerevisiae

Alignment Length:	350	Identity:	78/350 - (22%)
Similarity:	135/350 - (38%)	Gaps:	91/350 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QQVNENLLKAKLKLVAQKSQKNGGIITPNPSDTEDEAPEIAVPNKKPRLEQPAM--SMTPPPDQK 91
            ||:.:.|.:.:.|.:..         :.|.|.|..::....:.:::.|...|.:  |::.....|
Yeast   411 QQLQQQLNRVQHKQLTS---------SHNNSSTNMKSFNSDLYSRRQRASLPIIDDSLSYDLVNK 466

  Fly    92 LDDDQKAERVSVIMRVNSSGAVSSSSQ----DENSSSSTSCCSSSSNTNTSTSSVPPTVEDDYPE 152
            .|:|.|.:     |..||:  :|||.|    ....|.:.|..:..:.|..| :.:|...|:....
Yeast   467 QDEDPKND-----MLPNSN--LSSSQQFIKPSMILSDNASVIAKVATTGLS-NDMPFLTEEGEQN 523

  Fly   153 ANVWRNLKFKMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIKEEEIKPILTPIYVSPVASSA 217
            ||                      .||...::           |.:..:.|:      ||.:||:
Yeast   524 AN----------------------STPNFDLS-----------ITQMNMAPL------SPASSSS 549

  Fly   218 SQLI-------------------LLSTVAAQQSPTPVPKTPTMSEEK-----LTTRITAAQAAAT 258
            :.|.                   :.|::..::|..|:..|..::.::     .:...|...|..|
Yeast   550 TSLATNHFYHHFPQQGHHTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVT 614

  Fly   259 RSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRT-HTGEKK 322
            :.|  ..|:........:.|.:.........|:||.|  ..|.|.|.||:.|.||.|: |:.|:.
Yeast   615 KER--RPSYRRKSMTPSRRSSVVIESTKELEEKPFHC--HICPKSFKRSEHLKRHVRSVHSNERP 675

  Fly   323 FQCSVCQKKFMRSDHLSKHVKRHNK 347
            |.|.:|.|||.|||:||:|:|.|.|
Yeast   676 FACHICDKKFSRSDNLSQHIKTHKK 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	2/23 (9%)
		C2H2 Zn finger	265..287	CDD:275368	2/21 (10%)
		COG5048	<270..362	CDD:227381	30/78 (38%)
		zf-H2C2_2	279..306	CDD:290200	7/26 (27%)
		C2H2 Zn finger	295..317	CDD:275368	10/22 (45%)
		zf-H2C2_2	309..332	CDD:290200	10/23 (43%)
		zf-C2H2	323..345	CDD:278523	13/21 (62%)
		C2H2 Zn finger	325..345	CDD:275368	12/19 (63%)
MSN2	NP_013751.1	COG5048	127..594	CDD:227381	42/238 (18%)
		zf-C2H2_4	647..670	CDD:404733	11/24 (46%)
		C2H2 Zn finger	649..670	CDD:275368	10/22 (45%)
		zf-H2C2_2	661..687	CDD:404364	12/25 (48%)
		zf-C2H2	676..698	CDD:395048	13/21 (62%)
		C2H2 Zn finger	678..698	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030