DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cbt and Klf15

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_445988.2	Gene:	Klf15 / 85497	RGDID:	70918	Length:	415	Species:	Rattus norvegicus

Alignment Length:	336	Identity:	104/336 - (30%)
Similarity:	141/336 - (41%)	Gaps:	77/336 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 AVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAV----SSSSQDENSSSSTSCC 129
            :||.|:..|..|......|.|.........|.:...:..|....|    .|||:|..:.|..|..
  Rat   111 SVPVKEEHLCFPEFLSGDPDDVSRPFQPTLEEIEEFLEENMEAEVKEAPESSSRDLEACSQLSAG 175

  Fly   130 SSSSNTNTSTSS----VPPT--------------VEDDYPEANVWRNLKFKMNRKRAAEVALPPV 176
            |..|:.:..:..    .||.              ...|.|...:.:.....:.::..|..| .|.
  Rat   176 SHRSHLHPESGGRECRTPPPGGTSGGGTQGAGEGSAHDGPMPVLLQIQPVAVKQEAGAGPA-SPG 239

  Fly   177 QTPET-PVAKL--------------VTPPAPAE-CIKEEEIKPILTPIYVSPVASSASQLILLST 225
            |.||: .||:|              |.|.:... ..|...|.|:  ||...|:.|.:
  Rat   240 QAPESVKVAQLLVNIQGQTFALLPQVVPSSNLNLSSKFVRIAPV--PIAAKPIGSGS-------- 294

  Fly   226 VAAQQSPTPV--------PKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKA 282
                ..|.|.        ||.|                ||...::::|:||.|.|.|.|||||||
  Rat   295 ----LGPGPAGLLVGQKFPKNP----------------AAELLKMHKCTFPGCSKMYTKSSHLKA 339

  Fly   283 HQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRHNK 347
            |.|.||||:||.|.|..|..|||||||||||:|:|:|.|.:||.||:|||.||||||||:|.|..
  Rat   340 HLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRF 404

  Fly   348 DKANGVNRHVS 358
            .:::...|.::
  Rat   405 PRSSRAVRAIN 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	15/23 (65%)
		C2H2 Zn finger	265..287	CDD:275368	15/21 (71%)
		COG5048	<270..362	CDD:227381	54/89 (61%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	15/21 (71%)
		zf-H2C2_2	309..332	CDD:290200	14/22 (64%)
		zf-C2H2	323..345	CDD:278523	16/21 (76%)
		C2H2 Zn finger	325..345	CDD:275368	15/19 (79%)
Klf15	NP_445988.2	KLF15_N	3..320	CDD:410206	47/239 (20%)
		SFP1	<318..400	CDD:227516	54/81 (67%)
		C2H2 Zn finger	322..344	CDD:275368	15/21 (71%)
		C2H2 Zn finger	352..374	CDD:275368	15/21 (71%)
		C2H2 Zn finger	382..402	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910