DRSC/TRiP Functional Genomics Resources

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Protein Alignment cbt and KLF11

DIOPT Version :9

Sequence 1:NP_722636.1 Gene:cbt / 33224 FlyBaseID:FBgn0043364 Length:428 Species:Drosophila melanogaster
Sequence 2:NP_003588.1 Gene:KLF11 / 8462 HGNCID:11811 Length:512 Species:Homo sapiens


Alignment Length:446 Identity:133/446 - (29%)
Similarity:176/446 - (39%) Gaps:120/446 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 MDTLLPSPPATPPLRENKLEIVAKDEQQVNENLLKA-------KLKLVAQKSQKNG---GIITPN 57
            :.||..:||.:|.|.|.......  ..||.::  ||       :...|..::...|   |::...
Human   101 LSTLCITPPQSPDLVEPSTRTPV--SPQVTDS--KACTATDVLQSSAVVARALSGGAERGLLGLE 161

  Fly    58 PSDTEDEAPEIAVPNKKPRL----------EQPA--MSMTPPPDQKLDDDQKAER---------- 100
            |           ||:...|.          |.||  ......||.:|.|.::.|.          
Human   162 P-----------VPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQ 215

  Fly   101 -------------VSVIMRVNSSGA--VSSSSQDENSSSSTSCCSSSSNTNTSTSSVPPTVEDDY 150
                         ||....::.||.  ::...|......:...||            |...|:|.
Human   216 DTHLTDSLLSTNLVSCQPCLHKSGGLLLTDKGQQAGWPGAVQTCS------------PKNYENDL 268

  Fly   151 PEANVWRNLKFKMNRKRAAEVALPPVQTPETPV--------AKLVTPPAPAECIKEEEIKPILT- 206
            |.         |.....:..|..|||.....||        |.|..||.    :....::|||. 
Human   269 PR---------KTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQ----LSVGTVRPILAQ 320

  Fly   207 ------PIYVSPVASSASQLILLSTVAAQQSPTPVP---------KTPTMSEEKLTTRITAAQAA 256
                  |::|.|.....:.:::|...|.   |.|.|         .|..:........||::|..
Human   321 AAPAPQPVFVGPAVPQGAVMLVLPQGAL---PPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNC 382

  Fly   257 A-----TRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRT 316
            .     :|.|.|.||||.|.|.||||||||||.|.||||:||.|.|:.|||:|:||||||||:||
Human   383 VPQVDFSRRRNYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRT 447

  Fly   317 HTGEKKFQCSVCQKKFMRSDHLSKHVKRH-NKDKANGVNRHVSLANNNTSASVAAS 371
            |||||||.|.||.::|||||||:||.:|| ...|..|....|...|...||....|
Human   448 HTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAESPGS 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbtNP_722636.1 zf-C2H2 263..287 CDD:278523 18/23 (78%)
C2H2 Zn finger 265..287 CDD:275368 17/21 (81%)
COG5048 <270..362 CDD:227381 59/92 (64%)
zf-H2C2_2 279..306 CDD:290200 18/26 (69%)
C2H2 Zn finger 295..317 CDD:275368 15/21 (71%)
zf-H2C2_2 309..332 CDD:290200 17/22 (77%)
zf-C2H2 323..345 CDD:278523 13/21 (62%)
C2H2 Zn finger 325..345 CDD:275368 12/19 (63%)
KLF11NP_003588.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128 5/20 (25%)
COG5048 393..>449 CDD:227381 40/55 (73%)
zf-C2H2 394..418 CDD:278523 18/23 (78%)
C2H2 Zn finger 399..418 CDD:275368 14/18 (78%)
zf-H2C2_2 410..437 CDD:290200 18/26 (69%)
C2H2 Zn finger 426..448 CDD:275368 15/21 (71%)
zf-H2C2_2 440..463 CDD:290200 17/22 (77%)
zf-C2H2 454..476 CDD:278523 13/21 (62%)
C2H2 Zn finger 456..476 CDD:275368 12/19 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11801
eggNOG 1 0.900 - - E33208_3BHW9
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41554
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 1 1.000 - - X5472
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.800

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