DRSC/TRiP Functional Genomics Resources

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Protein Alignment cbt and Klf10

DIOPT Version :9

Sequence 1:NP_722636.1 Gene:cbt / 33224 FlyBaseID:FBgn0043364 Length:428 Species:Drosophila melanogaster
Sequence 2:NP_112397.1 Gene:Klf10 / 81813 RGDID:621652 Length:480 Species:Rattus norvegicus


Alignment Length:423 Identity:128/423 - (30%)
Similarity:174/423 - (41%) Gaps:124/423 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SPPATPPLRENKLEIVAK---DEQQVN---------------ENLLKAKLKLVAQKSQKNGGIIT 55
            ||.|.|||.:.:...|.:   |.|..|               :|..:.:..:..:.::||     
  Rat   139 SPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHINVEATRKN----- 198

  Fly    56 PNPSDTEDEAPEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQDE 120
                     .|..||...:|:         |.|....:..:||........|.||..|...|...
  Rat   199 ---------IPCAAVSPNRPK---------PEPSTAANGAEKAGTAPYDFAVPSSETVICRSSQP 245

  Fly   121 NSSSSTSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALP------PVQTP 179
            ..:|........|:...||..|||                            ||      |:...
  Rat   246 APTSPVQKSVLMSSPTVSTGGVPP----------------------------LPVICQMVPLPAN 282

  Fly   180 ETPVAKLV--TPPA--PAECIKEEEIKPIL---------TPIYVSPVASSASQLILLSTVAAQQS 231
            .:.|..:|  :||:  ||.|      .|:|         |.::|.|      |.::.|......|
  Rat   283 NSLVTTVVPSSPPSQPPAVC------SPVLFMGTQVPKGTVMFVVP------QPVVQSPKPPVVS 335

  Fly   232 P-----TPVPKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGER 291
            |     :|:...|..|..  ..|:| .|..::|.|.:.||.|.|||.||||||||||.|.||||:
  Rat   336 PNGTRLSPIAPAPGFSPS--AARVT-PQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEK 397

  Fly   292 PFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRHNKDKANGVNRH 356
            ||.|.|:.|::||:||||||||:|||||||||.|.:|.::|||||||:||.:||...|       
  Rat   398 PFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAK------- 455

  Fly   357 VSLANNNTSASVAASLCDASLHLRAIAPAGSSA 389
             .|.|.....|        .|:..|:.||.:||
  Rat   456 -KLPNWQMEVS--------KLNDIALPPATASA 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbtNP_722636.1 zf-C2H2 263..287 CDD:278523 17/23 (74%)
C2H2 Zn finger 265..287 CDD:275368 17/21 (81%)
COG5048 <270..362 CDD:227381 57/91 (63%)
zf-H2C2_2 279..306 CDD:290200 17/26 (65%)
C2H2 Zn finger 295..317 CDD:275368 14/21 (67%)
zf-H2C2_2 309..332 CDD:290200 16/22 (73%)
zf-C2H2 323..345 CDD:278523 12/21 (57%)
C2H2 Zn finger 325..345 CDD:275368 11/19 (58%)
Klf10NP_112397.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
KLF10_N 33..369 CDD:409241 60/295 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..83
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 97..146 4/6 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..222 5/28 (18%)
zf-C2H2 369..393 CDD:395048 17/23 (74%)
C2H2 Zn finger 374..393 CDD:275368 15/18 (83%)
zf-H2C2_2 385..412 CDD:404364 17/26 (65%)
C2H2 Zn finger 401..423 CDD:275368 14/21 (67%)
zf-C2H2 429..451 CDD:395048 12/21 (57%)
C2H2 Zn finger 431..451 CDD:275368 11/19 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11381
eggNOG 1 0.900 - - E33208_3BHW9
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 157 1.000 Inparanoid score I4188
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0012604
OrthoInspector 1 1.000 - - otm45675
orthoMCL 1 0.900 - - OOG6_110440
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.760

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