DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cbt and egr4

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001107925.1	Gene:	egr4 / 795099	ZFINID:	ZDB-GENE-080204-90	Length:	352	Species:	Danio rerio

Alignment Length:	277	Identity:	72/277 - (25%)
Similarity:	108/277 - (38%)	Gaps:	88/277 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VNSSGAVSSSSQDENSSSS--------------TSCCSSSSNTNTSTSSVPPTVEDDY------- 150
            :.|..::.:.|.||.:.:|              :||..........|||..|:..||.
Zfish   112 LGSPESLCNDSSDEFADTSAQQLAFPAIKSEFGSSCSGGDLFDGFCTSSHEPSDLDDIIDLLSPL 176

  Fly   151 -PEA----NVW---RNLKFKMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIKEEEIKPILTP 207
             ||.    :.|   ..|.|::                  |||     |||:.          ...
Zfish   177 GPETDSVLDTWIKQEPLDFQL------------------PVA-----PAPSH----------ENS 208

  Fly   208 IYVS-----PVASSASQLILLSTVAAQQSPTPVPKTPTMSEEKLTTRITAAQAAATRSRIYECSF 267
            :|:|     .:|.:...|:..:|.|.:..|                   .|:..|.|.:.:.|..
Zfish   209 LYISFPNAFGLADALDSLLATNTHAQRSKP-------------------RARKGAAREKPFSCPV 254

  Fly   268 PDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKF 332
            ..|.:.:.:|..|..|.|:|||.:||.|:  .|.:.|||||.|:.|.|||||||.|.|.||.::|
Zfish   255 ESCERRFSRSDELNRHVRIHTGHKPFQCR--VCLRCFSRSDHLTTHMRTHTGEKPFSCDVCARRF 317

  Fly   333 MRSDHLSKHVKRHNKDK 349
            .|||...:|::.|.|.:
Zfish   318 ARSDERKRHMRVHLKQR 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	6/23 (26%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	37/80 (46%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	13/22 (59%)
		zf-C2H2	323..345	CDD:278523	9/21 (43%)
		C2H2 Zn finger	325..345	CDD:275368	8/19 (42%)
egr4	NP_001107925.1	COG5048	229..>311	CDD:227381	34/102 (33%)
		C2H2 Zn finger	252..274	CDD:275368	6/21 (29%)
		zf-H2C2_2	266..291	CDD:290200	11/26 (42%)
		COG5048	278..>344	CDD:227381	29/59 (49%)
		C2H2 Zn finger	282..302	CDD:275368	10/21 (48%)
		zf-H2C2_2	294..319	CDD:290200	14/24 (58%)
		C2H2 Zn finger	310..330	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940