DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cbt and Sp2

DIOPT Version :9

Sequence 1:NP_722636.1 Gene:cbt / 33224 FlyBaseID:FBgn0043364 Length:428 Species:Drosophila melanogaster
Sequence 2:NP_084496.2 Gene:Sp2 / 78912 MGIID:1926162 Length:613 Species:Mus musculus


Alignment Length:416 Identity:112/416 - (26%)
Similarity:171/416 - (41%) Gaps:115/416 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LLPSPPATPPLRENK------LEI----VAKDEQ-------QVNENLLKAKLKLVAQKSQKNG-- 51
            ||...|.||..:.||      |.:    ||..||       ...:|:::|...|:..:|...|  
Mouse   231 LLTESPPTPLSKTNKKARKKSLPVSQPSVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQP 295

  Fly    52 ------GIITPNPSDTEDEAPEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAER-----VSVIM 105
                  .::.|.    .::...:.:|.:..|:.|.|.:..|...||...:.:.:.     ..|.:
Mouse   296 AVVQQVQVVPPK----AEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTEPTPTQVYI 356

  Fly   106 RVNSSGAVSSSSQDENSSSSTSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAE 170
            |..|....:...||  |..:|:..:|:...|:.....|              :|.....:..|| 
Mouse   357 RTPSGEVQTVLVQD--SPPATAATTSTVTCNSPALRAP--------------HLSGTSKKHSAA- 404

  Fly   171 VALPPVQTPETPVAKLVTPPAPAECIKEEEIKPILTPIYVSPVASSASQLILLSTVAAQQSPTPV 235
                 :...|.|:.|:    |||..|         ..:..:.:|::|..:..::....|....||
Mouse   405 -----ILRKERPLPKI----APAGSI---------ISLNAAQLAAAAQAMQTININGVQVQGVPV 451

  Fly   236 PKTPTMSEEKLTTRITA-------------------------AQAAATRSRI------------- 262
            ..|.|..:::||.:..:                         ||....|.|:             
Mouse   452 TITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGEAQPGEKRRRMACTCPNCKDGEKR 516

  Fly   263 --------YECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTG 319
                    :.|..|||||.:.|:|.|:||.|:|||||||:|.|..|.|||:|||||.||.|||||
Mouse   517 SGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTG 581

  Fly   320 EKKFQCSVCQKKFMRSDHLSKHVKRH 345
            :|:|:|:.|||:|||||||:||.|.|
Mouse   582 DKRFECAQCQKRFMRSDHLTKHYKTH 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbtNP_722636.1 zf-C2H2 263..287 CDD:278523 12/23 (52%)
C2H2 Zn finger 265..287 CDD:275368 12/21 (57%)
COG5048 <270..362 CDD:227381 51/76 (67%)
zf-H2C2_2 279..306 CDD:290200 17/26 (65%)
C2H2 Zn finger 295..317 CDD:275368 14/21 (67%)
zf-H2C2_2 309..332 CDD:290200 15/22 (68%)
zf-C2H2 323..345 CDD:278523 15/21 (71%)
C2H2 Zn finger 325..345 CDD:275368 14/19 (74%)
Sp2NP_084496.2 zf-C2H2 525..549 CDD:278523 12/23 (52%)
C2H2 Zn finger 530..549 CDD:275368 11/18 (61%)
zf-H2C2_2 542..568 CDD:290200 17/25 (68%)
C2H2 Zn finger 557..579 CDD:275368 14/21 (67%)
zf-H2C2_2 571..594 CDD:290200 15/22 (68%)
zf-C2H2 585..607 CDD:278523 15/21 (71%)
C2H2 Zn finger 587..607 CDD:275368 14/19 (74%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.040

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