DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and ZNF174

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001334797.1	Gene:	ZNF174 / 7727	HGNCID:	12963	Length:	407	Species:	Homo sapiens

Alignment Length:	278	Identity:	67/278 - (24%)
Similarity:	103/278 - (37%)	Gaps:	66/278 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQDENSSSSTSCCSSSSNTNT 137
            |.|.|::|...:......::..|.|                 .:.|.|.:..:..|..|:..:..
Human   194 KSPLLQEPTPKLAGTEAPRMRSDNK-----------------ENPQQEGAKGAKPCAVSAGRSKG 241

  Fly   138 STSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIKEEEIK 202
            :....|..           |.......|....:|:.|..|.|.....:        .|    .::
Human   242 NGLQNPEP-----------RGANMSEPRLSRRQVSSPNAQKPFAHYQR--------HC----RVE 283

  Fly   203 PILTPIYVSPVASSASQLILLSTVAAQQSPTPVPKTPTMSEEKLTTRITAAQAAATRS--RIYEC 265
            .|.:|:...|:...                    |.....:..|:.|:.......|||  :.|:|
Human   284 YISSPLKSHPLREL--------------------KKSKGGKRSLSNRLQHLGHQPTRSAKKPYKC 328

  Fly   266 SFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQK 330
            .  ||||::..:|.||.|:||||||||:.|  ..|...|.|...|..|:|.|||||.:||..|.|
Human   329 D--DCGKSFTWNSELKRHKRVHTGERPYTC--GECGNCFGRQSTLKLHQRIHTGEKPYQCGQCGK 389

  Fly   331 KFMRSDHLSKHVKRHNKD 348
            .|.:|.:|.:|.:.|:.|
Human   390 SFRQSSNLHQHHRLHHGD 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	11/23 (48%)
		C2H2 Zn finger	265..287	CDD:275368	10/21 (48%)
		COG5048	<270..362	CDD:227381	37/79 (47%)
		zf-H2C2_2	279..306	CDD:290200	14/26 (54%)
		C2H2 Zn finger	295..317	CDD:275368	7/21 (33%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	8/21 (38%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
ZNF174	NP_001334797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
ZNF174	NP_001334797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..270		15/103 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4872
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950