DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and KLF10

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_005646.1	Gene:	KLF10 / 7071	HGNCID:	11810	Length:	480	Species:	Homo sapiens

Alignment Length:	412	Identity:	129/412 - (31%)
Similarity:	176/412 - (42%)	Gaps:	105/412 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTLLPSPP---------ATPPLRENKLEIVAKDEQQVNENLLKAKLKLVAQKSQKNGGIITPNPS 59
            :.|||..|         .|||...:..|     ..||: ||:......|..||.          |
Human    75 ENLLPGTPDFHTIPAFCLTPPYSPSDFE-----PSQVS-NLMAPAPSTVHFKSL----------S 123

  Fly    60 DTEDEAPEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSS----------GAVS 114
            ||  ..|.||.|.|:.  |:..:|....|        ||:..|||.....:          .|.|
Human   124 DT--AKPHIAAPFKEE--EKSPVSAPKLP--------KAQATSVIRHTADAQLCNHQTCPMKAAS 176

  Fly   115 SSSQDENS-SSSTSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAA---EVALPP 175
            ..:...|| ...|.....::..|...::|.|.      .:...||....::.|.:|   :.::|.
Human   177 ILNYQNNSFRRRTHLNVEAARKNIPCAAVSPN------RSKCERNTVADVDEKASAALYDFSVPS 235

  Fly   176 VQT--------PETPVAK--LVTPPA---------PAEC--IKEEEIKPILT-----------PI 208
            .:|        |.:|..|  ||:|||         |..|  :......|::|           |.
Human   236 SETVICRSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPA 300

  Fly   209 YVSPVASSASQ------LILLSTVAAQQSPTPV---------PKTPTMSEEKLTTRITAAQAAAT 258
            ...||....:|      :.::.....|.|..||         |..|.........::| .|..::
Human   301 VCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGTRLSPIAPAPGFSPSAAKVT-PQIDSS 364

  Fly   259 RSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKF 323
            |.|.:.||.|.|||.||||||||||.|.||||:||.|.|:.|::||:||||||||:|||||||||
Human   365 RIRSHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKF 429

  Fly   324 QCSVCQKKFMRSDHLSKHVKRH 345
            .|.:|.::|||||||:||.:||
Human   430 ACPMCDRRFMRSDHLTKHARRH 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	17/23 (74%)
		C2H2 Zn finger	265..287	CDD:275368	17/21 (81%)
		COG5048	<270..362	CDD:227381	55/76 (72%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	14/21 (67%)
		zf-H2C2_2	309..332	CDD:290200	16/22 (73%)
		zf-C2H2	323..345	CDD:278523	12/21 (57%)
		C2H2 Zn finger	325..345	CDD:275368	11/19 (58%)
KLF10	NP_005646.1	zf-C2H2	369..393	CDD:278523	17/23 (74%)
		COG5048	374..>424	CDD:227381	36/49 (73%)
		C2H2 Zn finger	374..393	CDD:275368	15/18 (83%)
		zf-H2C2_2	385..412	CDD:290200	17/26 (65%)
		C2H2 Zn finger	401..423	CDD:275368	14/21 (67%)
		zf-H2C2_2	415..438	CDD:290200	16/22 (73%)
		zf-C2H2	429..451	CDD:278523	12/21 (57%)
		C2H2 Zn finger	431..451	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012604
OrthoInspector	1	1.000	-	-		otm41554
orthoMCL	1	0.900	-	-		OOG6_110440
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.810