DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and Klf15

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_006506534.1	Gene:	Klf15 / 66277	MGIID:	1929988	Length:	520	Species:	Mus musculus

Alignment Length:	379	Identity:	101/379 - (26%)
Similarity:	154/379 - (40%)	Gaps:	105/379 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ATPPLRENKL---EIVAKDEQQVN----------ENLLKAKLKLVAQKSQKNGGIITPNPSDTED 63
            |:.|::|...   |.::.|...|:          |..|:..::...:::.:||       |...:
Mouse   215 ASVPVKEEHFCFPEFLSGDTDDVSRPFQPTLEEIEEFLEENMEAEVKEAPENG-------SRDLE 272

  Fly    64 EAPEIAVPNKKPRLEQPAMS---MTPPPD-------QKLDDDQKAE-RVSVIMRVN--------S 109
            ...:::..:.:..|...:..   .||||.       |...:....: .|.|::::.        .
Mouse   273 TCSQLSAGSHRSHLHPESAGRERCTPPPGGTSGGGAQSAGEGPAHDGPVPVLLQIQPVAVKQEAG 337

  Fly   110 SGAVSSSSQDENSSSSTSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALP 174
            :|..|.....|    |........|....|.::.|.|   .|.:|:  ||..|.       |.:.
Mouse   338 TGPASPGQAPE----SVKVAQLLVNIQGQTFALLPQV---VPSSNL--NLPSKF-------VRIA 386

  Fly   175 PVQTPETPVAKLVTPPAPAECIKEEEIKPILTPIYVSPVASSASQLILLSTVAAQQSPTPVPKTP 239
            ||.....|:......|.||..:..::.                                  ||.|
Mouse   387 PVPIAAKPIGSGSLGPGPAGLLVGQKF----------------------------------PKNP 417

  Fly   240 TMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRF 304
                            ||...::::|:||.|.|.|.||||||||.|.||||:||.|.|..|..||
Mouse   418 ----------------AAELLKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRF 466

  Fly   305 SRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRHNKDKANGVNRHVS 358
            |||||||||:|:|:|.|.:||.||:|||.||||||||:|.|...:::...|.::
Mouse   467 SRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRFPRSSRAVRAIN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	15/23 (65%)
		C2H2 Zn finger	265..287	CDD:275368	15/21 (71%)
		COG5048	<270..362	CDD:227381	54/89 (61%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	15/21 (71%)
		zf-H2C2_2	309..332	CDD:290200	14/22 (64%)
		zf-C2H2	323..345	CDD:278523	16/21 (76%)
		C2H2 Zn finger	325..345	CDD:275368	15/19 (79%)
Klf15	XP_006506534.1	SFP1	<423..505	CDD:227516	54/81 (67%)
		C2H2 Zn finger	427..449	CDD:275368	15/21 (71%)
		C2H2 Zn finger	457..479	CDD:275368	15/21 (71%)
		zf-H2C2_2	471..496	CDD:372612	16/24 (67%)
		C2H2 Zn finger	487..507	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940