DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cbt and klf11a

DIOPT Version :9

Sequence 1:NP_722636.1 Gene:cbt / 33224 FlyBaseID:FBgn0043364 Length:428 Species:Drosophila melanogaster
Sequence 2:XP_021324131.1 Gene:klf11a / 560787 ZFINID:ZDB-GENE-030131-3568 Length:479 Species:Danio rerio


Alignment Length:438 Identity:127/438 - (28%)
Similarity:189/438 - (43%) Gaps:96/438 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDMDTLLPSPPATPPLRENKLEIVAKDEQQVNENLLKAKLKLVAQKSQKNGGIITPNPSDTEDEA 65
            :.:.:|..:||.:|...|.....|.  ...|..:.||...:|.:..:.:....::.:||.|    
Zfish    87 VSLSSLCMTPPHSPSFAETSGTAVL--STSVACSGLKPHPRLCSALTNRAACHVSLHPSTT---- 145

  Fly    66 PEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQDENSSSSTSCCS 130
                            :.:.|.|.|..:........|||..      .:..|.|.|..|:|    
Zfish   146 ----------------VLLNPAPPQTAEQPSLRRATSVIRH------TADRSMDHNIPSTT---- 184

  Fly   131 SSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKM----------NRKRAAE------VALPPVQT- 178
             :......:|.:||    ::.|:|.  :||.::          ..:|.|.      :|:|..|: 
Zfish   185 -TGQEKPCSSEIPP----EHTESNT--SLKGEVQICSSPCDSAEPERTAPSPDSTGIAIPTSQST 242

  Fly   179 -PETP-------------------VAKLVTPPAPAECIKEEEIKPILTPIYV-SPVASSASQLIL 222
             |::|                   ::..|..|...:....:.|.|...|:.| ||||......::
Zfish   243 IPQSPMSSPPVLCQVFPVNGQTGIISAFVQTPVQMQTSGSKPILPHSQPLLVGSPVAQGTVMFVV 307

  Fly   223 LSTVAAQQSPTPVPKTPTMSEEKLTTRITA------------AQAAATRSRIYECSFPDCGKNYF 275
            ..:..:|.| |......|:...||.....|            .|:..:|.|.|.|:|..|.|.||
Zfish   308 PQSQVSQSS-TCQQSVVTLGNTKLLPLAPAPVYVPSGQSSGVTQSDFSRRRNYVCNFQGCKKTYF 371

  Fly   276 KSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSK 340
            ||||||||.|.||||:||.|.||.|||:|:||||||||:|||||||||.|.||:::|||||||:|
Zfish   372 KSSHLKAHLRTHTGEKPFSCHWEGCDKKFARSDELSRHRRTHTGEKKFVCPVCERRFMRSDHLTK 436

  Fly   341 HVKRHNKDKANGVNRHVSLANNNTSAS-VAASLCDASLHLRAIAPAGS 387
            |.:||...|     |..:..|.....: :|.|...:|:.|..:.||.:
Zfish   437 HARRHMTTK-----RSTAWPNEVRDVNKMATSQAPSSIPLSVLLPASN 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbtNP_722636.1 zf-C2H2 263..287 CDD:278523 16/23 (70%)
C2H2 Zn finger 265..287 CDD:275368 15/21 (71%)
COG5048 <270..362 CDD:227381 59/91 (65%)
zf-H2C2_2 279..306 CDD:290200 19/26 (73%)
C2H2 Zn finger 295..317 CDD:275368 16/21 (76%)
zf-H2C2_2 309..332 CDD:290200 17/22 (77%)
zf-C2H2 323..345 CDD:278523 13/21 (62%)
C2H2 Zn finger 325..345 CDD:275368 12/19 (63%)
klf11aXP_021324131.1 MotB_plug <203..345 CDD:330912 27/144 (19%)
C2H2 Zn finger 361..383 CDD:275368 15/21 (71%)
zf-H2C2_2 375..402 CDD:316026 19/26 (73%)
C2H2 Zn finger 391..413 CDD:275368 16/21 (76%)
zf-H2C2_2 405..428 CDD:316026 17/22 (77%)
zf-C2H2 419..441 CDD:306579 13/21 (62%)
C2H2 Zn finger 421..441 CDD:275368 12/19 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11699
eggNOG 1 0.900 - - E33208_3BHW9
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 167 1.000 Inparanoid score I4148
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24441
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 1 1.000 - - X5472
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
87.850

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