DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and sp2

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001093452.2	Gene:	sp2 / 556835	ZFINID:	ZDB-GENE-080410-1	Length:	610	Species:	Danio rerio

Alignment Length:	448	Identity:	114/448 - (25%)
Similarity:	172/448 - (38%)	Gaps:	115/448 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SPPATP-PLRENKLEIVAKDEQQVNENLLKAKLKLVAQKSQKNGGIITPNPSDTED--------E 64
            :||..| |:.::|...:....|:..:|.......:|...|    |:..|....|.|        |
Zfish   171 APPLAPAPVPQHKTVAIKPSTQKRRQNNASVNANIVRLPS----GLTLPLNVTTGDVGGAQVLTE 231

  Fly    65 APEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQD----ENSSSS 125
            .....|..|:.|..|.|::...|..|.......||:|..::...::..:..:..:    :|...|
Zfish   232 TAAAPVKPKRGRKRQVAIAAPAPAPQPASPPPVAEQVEALLIETTADNIIQAGNNLLIVQNPGGS 296

  Fly   126 -----------------------------TSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKF 161
                                         ....|::........:|.|:|:...||..... :|.
Zfish   297 QPAVVQQVQLLQQKSDQQVVQIPPQALKVVQAASATLPPVPQRQTVTPSVQVSPPEPTQVL-IKT 360

  Fly   162 KMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIK-------EEEIKPILTP-------IYVSP 212
            .....:|.::....|.||.||    .:.|.||...|       :|...|.:.|       :..:.
Zfish   361 ASGEWQAVQIQETTVTTPTTP----TSTPTPAVVTKKVQTGTRKERTLPKIAPAGGGLITLNAAQ 421

  Fly   213 VASSAS--QLILLSTVAAQQSPTPV-------------------------PKTPTMSEEKLTTRI 250
            :||:|.  |.|.::.|..|..|..:                         .:|.||..|:..|..
Zfish   422 LASAAQAVQTININGVQVQGVPVTITNAGGQQHLTVQTVPSAGLQLGSVQTQTQTMQIEQTQTLA 486

  Fly   251 TAAQA-AATRSRIYECSFPD----------------------CGKNYFKSSHLKAHQRVHTGERP 292
            ...|. ...:.|...|:.|:                      |.|.:.|:|.|:||.|:||||||
Zfish   487 LELQTQPGEKKRRMACTCPNCKDAEKKPGEVGKRKHICHIAGCEKTFRKTSLLRAHVRLHTGERP 551

  Fly   293 FICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRHNKDKA 350
            |:|.|..|.|||:|||||.||.|||||:|:|:|:.|||:|||||||:||.|.|...|:
Zfish   552 FVCNWVFCGKRFTRSDELQRHARTHTGDKRFECNKCQKRFMRSDHLTKHYKTHINTKS 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	10/45 (22%)
		C2H2 Zn finger	265..287	CDD:275368	10/43 (23%)
		COG5048	<270..362	CDD:227381	51/81 (63%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	14/21 (67%)
		zf-H2C2_2	309..332	CDD:290200	15/22 (68%)
		zf-C2H2	323..345	CDD:278523	15/21 (71%)
		C2H2 Zn finger	325..345	CDD:275368	14/19 (74%)
sp2	NP_001093452.2	C2H2 Zn finger	524..546	CDD:275368	8/21 (38%)
		COG5048	<529..>584	CDD:227381	35/54 (65%)
		zf-H2C2_2	539..565	CDD:290200	17/25 (68%)
		C2H2 Zn finger	554..576	CDD:275368	14/21 (67%)
		zf-H2C2_2	568..591	CDD:290200	15/22 (68%)
		zf-C2H2	582..604	CDD:278523	15/21 (71%)
		C2H2 Zn finger	584..604	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.040