DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and klf4

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001017280.1	Gene:	klf4 / 550034	XenbaseID:	XB-GENE-1015049	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	111/389 - (28%)
Similarity:	148/389 - (38%)	Gaps:	101/389 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSPPATPPLRENKLEIVAKDEQQVNENLLKAKLKLVAQ---KSQKNGGII------------TPN 57
            |.||||.|              .....|.......|.|   ..:.:||.:            |.|
Frog    68 PPPPATLP--------------DTMSALSSTTCNFVYQVRCPQESSGGTLMYNARDPTMSSATFN 118

  Fly    58 PSDTEDEAP------EIAVPNKKP--RLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVS 114
            .:|..|.:|      |:..|:..|  ..:||..|:......|..........::.:|.|:||..|
Frog   119 LADINDVSPSGGFVAELMRPDLDPVFMQQQPQASLQGKFVLKTTVSMGDYGQTISVRKNNSGIDS 183

  Fly   115 SSS-------------QDENSSSSTSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRK 166
            ..|             :.|.|||.||.|........|.|         ..|....|.|..:.|:.
Frog   184 PLSYTTHQLPRVCQKIKQEPSSSCTSACPMDGQGQQSQS---------MREFQAGRGLPIRTNQS 239

  Fly   167 RAAEVAL-----PPVQTPETPVAKLVTPPAPAECIKEEEIKPILTPIYVSPVASSASQLILLSTV 226
            .:.|..:     ...||  ...:.|..|||                     ..:|||    .|..
Frog   240 LSPEELMGRDCHSSSQT--LSHSSLPIPPA---------------------YHTSAS----FSHF 277

  Fly   227 AAQQSPTPVPKTPTMSEEKLTTRITAAQAA----------ATRSRIYECSFPDCGKNYFKSSHLK 281
            .:.|..|.:|.|....:|.|||.....:.:          ..|:..:.|.:..|||.|.||||||
Frog   278 TSDQPQTQLPPTQLQYQELLTTGGCIPEESKPKRGRKSWPRKRTATHTCEYAGCGKTYTKSSHLK 342

  Fly   282 AHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345
            ||.|.||||:|:.|.||.|..:|:|||||:||.|.|||.:.|||..|.:.|.|||||:.|:|||
Frog   343 AHLRTHTGEKPYHCDWEGCGWKFARSDELTRHYRKHTGHRPFQCQRCDRAFSRSDHLALHMKRH 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	14/23 (61%)
		C2H2 Zn finger	265..287	CDD:275368	14/21 (67%)
		COG5048	<270..362	CDD:227381	48/76 (63%)
		zf-H2C2_2	279..306	CDD:290200	16/26 (62%)
		C2H2 Zn finger	295..317	CDD:275368	13/21 (62%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	12/21 (57%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
klf4	NP_001017280.1	zf-C2H2	324..348	CDD:333835	14/23 (61%)
		C2H2 Zn finger	326..348	CDD:275368	14/21 (67%)
		C2H2 Zn finger	356..378	CDD:275368	13/21 (62%)
		zf-H2C2_2	370..395	CDD:372612	13/24 (54%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910