DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and sp2

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_031749963.1	Gene:	sp2 / 549560	XenbaseID:	XB-GENE-968274	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	392	Identity:	106/392 - (27%)
Similarity:	163/392 - (41%)	Gaps:	106/392 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PPATP-PLRENKLEIVAKDEQQVNENLLKAKLKLVAQKSQKNG-----GIITPNPSDTEDEAPEI 68
            ||:.| |...|:.::.....:...||:|:|...|:..:|...|     .::.|. :||:    .:
Frog   241 PPSIPVPGSPNQDQVETVVIETTAENILQAGNNLLIVQSPSTGQHAVLQVMQPK-TDTQ----LV 300

  Fly    69 AVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQDENSSSSTSCCSSSS 133
            .:|.:..|:.|.|.:..|...||.....:.....:.:| .:||.|.:....|..::...|.||:.
Frog   301 QIPQQALRVVQAASATLPTVPQKPVQTPECTPTQLYIR-TASGDVQAVVMQEAPAAPQPCSSSAG 364

  Fly   134 NTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALPPVQTP---ETPVAKLVTPPAPAEC 195
            ...|.|.:                                 ||:.|   |..:||:    |||..
Frog   365 PIVTQTGT---------------------------------PVKNPLRKERSLAKI----APAGS 392

  Fly   196 IKEEEIKPILTPIYVSPVASSASQLILLSTVAAQQ--SPTPVPKTPTMSEEKLTTRITA------ 252
            :.......:.|       |:...|.|.::.|:.|.  :.|..|..|.:|.:.:::...|
Frog   393 LINLNTTQLTT-------AAQGIQTININGVSMQMPVTITSTPGQPQLSVQNVSSGNVAISGLSP 450

  Fly   253 --------------AQAAATRSRI----------------------YECSFPDCGKNYFKSSHLK 281
                          .|....|.|:                      :.|..|:||:.:.|:|.|:
Frog   451 SQIQLQMEQALSGELQPGEKRRRVACTCPNCKDGEKGRWGPPGRKRHVCHIPECGRTFRKTSLLR 515

  Fly   282 AHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTH---TGEKKFQCSVCQKKFMRSDHLSKHVK 343
            ||.|:|||||||:|.|..|.|||:|||||.||.|||   ||:|:|:|..|||:|.||||:|||.|
Frog   516 AHVRLHTGERPFVCNWGFCTKRFTRSDELQRHARTHTGVTGDKRFECPQCQKRFTRSDHVSKHFK 580

  Fly   344 RH 345
            .|
Frog   581 TH 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	10/23 (43%)
		C2H2 Zn finger	265..287	CDD:275368	10/21 (48%)
		COG5048	<270..362	CDD:227381	49/79 (62%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	14/21 (67%)
		zf-H2C2_2	309..332	CDD:290200	15/25 (60%)
		zf-C2H2	323..345	CDD:278523	14/21 (67%)
		C2H2 Zn finger	325..345	CDD:275368	13/19 (68%)
sp2	XP_031749963.1	SP2_N	27..498	CDD:411776	55/306 (18%)
		C2H2 Zn finger	502..521	CDD:275368	9/18 (50%)
		zf-H2C2_2	514..540	CDD:404364	17/25 (68%)
		C2H2 Zn finger	529..551	CDD:275368	14/21 (67%)
		zf-H2C2_2	543..571	CDD:404364	16/27 (59%)
		C2H2 Zn finger	562..582	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.130