DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and klf2

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001016764.1	Gene:	klf2 / 549518	XenbaseID:	XB-GENE-485035	Length:	373	Species:	Xenopus tropicalis

Alignment Length:	358	Identity:	100/358 - (27%)
Similarity:	140/358 - (39%)	Gaps:	109/358 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KLDDDQKAERVSV----IMRVNSSGAVSSSSQDENSSS------------------------STS 127
            |.|.:.|:.|.|.    :|:  |..|.|:..:||:.::                        |.|
Frog    21 KCDYESKSPRSSCGIPDVMQ--SPDAFSTKKEDEDLNNVLEFVLAMGGDKSVQICGEYSMAPSES 83

  Fly   128 C---CSSSSNTNTSTSSVPPTVE-------------DDY-PEANVWRNLKFKMNRKRAAEVALPP 175
            |   .:|.|..:.||...||...             |:| ..:||........|......:...|
Frog    84 CNYYQTSPSPGSYSTDHSPPPYSSGSLMTELIRSDMDNYCHPSNVQGRFFVTSNFDFPDTIKAEP 148

  Fly   176 VQTPETPVAKLVTPPAPAECIK-EEEIKPILTPIYVSPVASSASQL------------ILLSTVA 227
            ......||..:|    |..|.| ::|........|..|..:::.|:            |:||...
Frog   149 DMDSYGPVMGMV----PQSCTKIKQEGSTACMMAYEQPRLANSPQMGGPDTPPLSPDDIMLSECQ 209

  Fly   228 AQ--------------------QSPTPVPKTPT--MSEEKLTTRITAAQAAAT------------ 258
            :|                    |||.....|..  |.|:.|..:.:.|:...|
Frog   210 SQLMCHPSVPYGHNYQHTGFHHQSPVQYQNTSQYGMFEDNLPMQPSIARGMITPPCSPLEILDTK 274

  Fly   259 -----------RSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSR 312
                       |:..:.||:..|||.|.||||||||.|.||||:|:.|.||.|..:|:|||||:|
Frog   275 PKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWEGCGWKFARSDELTR 339

  Fly   313 HKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345
            |.|.|||.:.|||.:|.:.|.|||||:.|:|||
Frog   340 HFRKHTGHRPFQCHLCDRAFSRSDHLALHMKRH 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	15/23 (65%)
		C2H2 Zn finger	265..287	CDD:275368	15/21 (71%)
		COG5048	<270..362	CDD:227381	48/76 (63%)
		zf-H2C2_2	279..306	CDD:290200	16/26 (62%)
		C2H2 Zn finger	295..317	CDD:275368	13/21 (62%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	12/21 (57%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
klf2	NP_001016764.1	COG5048	<285..368	CDD:227381	47/82 (57%)
		C2H2 Zn finger	292..314	CDD:275368	15/21 (71%)
		C2H2 Zn finger	322..344	CDD:275368	13/21 (62%)
		zf-H2C2_2	336..361	CDD:372612	13/24 (54%)
		C2H2 Zn finger	352..372	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000