DRSC/TRiP Functional Genomics Resources

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Protein Alignment cbt and KLF3

DIOPT Version :9

Sequence 1:NP_722636.1 Gene:cbt / 33224 FlyBaseID:FBgn0043364 Length:428 Species:Drosophila melanogaster
Sequence 2:NP_057615.3 Gene:KLF3 / 51274 HGNCID:16516 Length:345 Species:Homo sapiens


Alignment Length:359 Identity:94/359 - (26%)
Similarity:143/359 - (39%) Gaps:106/359 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 VPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQDENSSSSTSCCS---- 130
            ||.|:..::..::|.   |...::.          |:.|..|.:.|:...|....:....|    
Human     7 VPVKQEAMDPVSVSY---PSNYMES----------MKPNKYGVIYSTPLPEKFFQTPEGLSHGIQ 58

  Fly   131 -SSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALPPVQTP-ETPVAKLVTPPAPA 193
             ...:...:..|.||:.      .|...:|||..:.:||:    |.:..| .:|..|..:||:|.
Human    59 MEPVDLTVNKRSSPPSA------GNSPSSLKFPSSHRRAS----PGLSMPSSSPPIKKYSPPSPG 113

  Fly   194 --------------------ECIKEEEIKPILTPIYVSPV----ASSASQLILLSTVAAQQSPTP 234
                                ..|:...|.|::.|:.|.||    .|...|.:::|.....::.:.
Human   114 VQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSS 178

  Fly   235 VPKTPT-------MSEEK----------------------LTTRITAAQA--------------- 255
            ..:.|.       :|::|                      |...::..||               
Human   179 SMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGK 243

  Fly   256 ---------AATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELS 311
                     ...:.||:.|.:..|.|.|.||||||||:|.||||:|:.|.||.|..:|:|||||:
Human   244 RPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELT 308

  Fly   312 RHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345
            ||.|.|||.|.|||..|.:.|.|||||:.|.|||
Human   309 RHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRH 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbtNP_722636.1 zf-C2H2 263..287 CDD:278523 13/23 (57%)
C2H2 Zn finger 265..287 CDD:275368 13/21 (62%)
COG5048 <270..362 CDD:227381 48/76 (63%)
zf-H2C2_2 279..306 CDD:290200 16/26 (62%)
C2H2 Zn finger 295..317 CDD:275368 13/21 (62%)
zf-H2C2_2 309..332 CDD:290200 13/22 (59%)
zf-C2H2 323..345 CDD:278523 12/21 (57%)
C2H2 Zn finger 325..345 CDD:275368 10/19 (53%)
KLF3NP_057615.3 Repressor domain 1..74 13/79 (16%)
KLF3_N 49..260 CDD:410554 34/220 (15%)
9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868 60..68 0/7 (0%)
CTBP-binding motif 61..65 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..112 15/55 (27%)
zf-C2H2 260..284 CDD:395048 13/23 (57%)
C2H2 Zn finger 262..284 CDD:275368 13/21 (62%)
C2H2 Zn finger 292..314 CDD:275368 13/21 (62%)
zf-H2C2_2 306..331 CDD:404364 14/24 (58%)
C2H2 Zn finger 322..342 CDD:275368 10/19 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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